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Items where Research Institute is Biomedical Sciences Research Institute > Molecular Medicine > Neuroscience & Neurodegenerative Diseases

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Book (edited)

Holscher, Christian and Munk, M, eds. (2008) Mechanisms of information processing in the Brain: Information Processing by Neuronal Population. 666 pp. Cambridge University Press. ISBN ISBN 978-0-521-87303-1 [Book (edited)]

Book section

Holscher, Christian (2011) Protective roles of the incretin hormones Glucagon-Like Peptide-1 and Glucose-dependent Insolinotropic Polypeptide hormones in neurodegeneration. In: Alzheimer's disease. InTech publishing, pp. 123-184. ISBN ISBN
978-953-307-466-5 [Book section]

Holscher, Christian (2010) Höhere Verarbeitungsprozesse. In: Taschenlehrbuch Biologie, Zoologie. Thieme Verlag, pp. 551-584. ISBN ISBN 978-3-13-144841-5 [Book section]

Holscher, Christian (2010) The role of GLP-1 in neuronal activity and neurodegeneration. In: Vitamins and Hormones: INCRETINS AND INSULIN SECRETION. Academic Press/Elsevier, pp. 331-354. ISBN ISBN: 978-0-12-381517-0 [Book section]

Holscher, Christian (2008) Functional roles of Theta and Gamma oscillations in the association and dissociation of neuronal networks in primates and rodents. In: Information Processing by Neuronal Populations. (Eds: Holscher, Christian and Munk, M), Cambridge University Press, pp. 151-173. ISBN ISBN 978-0-521-87303-1 [Book section]

Holscher, Christian (2008) How could populations of neurons encode information? In: Information Processing by Neuronal Populations. (Eds: Holscher, Christian and Munk, M), Cambridge University Press, pp. 3-20. ISBN ISBN 978-0-521-87303-1 [Book section]

Saetzler, Kurt (2001) 3-D Rekonstruktion von Serienschnitten. In: Forschung und wissenschaftliches Rechnen, Beiträge zum Heinz-Billing-Preis 2000. (Eds: Plesser, T. and Hayd, H.), GWDG, pp. 31-47. ISBN 0176-2516 [Book section]

Eils, R. and Saetzler, Kurt (1999) Shape Reconstruction from Volumetric Data. In: Handbook of Computer Vision and Applications. (Eds: Jähne, B., Haußecker, H. and Geißler, P.), Academic Press, San Diego, London, Boston, New York, Sydney, Tokyo, Toronto, pp. 791-815. ISBN 0123797705 [Book section]

Eils, R., Saracoglu, K. and Saetzler, Kurt (1999) Morphological parameters, medial lines and skeletons computed in the 3D--Voronoi diagram with applications to 3D CLSM images. In: Focus on Multidimensional Microscopy. (Eds: Cheng, P.C., Hwang, P.P., Wu, J.L., Wang, G. and Kim, H.), World Scientific Publishing, Singapore, pp. 34-56. ISBN 9810239920 [Book section]

Conference contribution

Saetzler, Kurt, McCanny, P., Rodriguez, E.P., and R.M. Bruno, H. Horstmann and Denk, W. (2009) A fuzzy algorithm to trace stained neurons in serial block-face scanning electron microscopy image series. In: 13th International Machine Vision and Image Processing Conference, Dublin. UNSPECIFIED. 6 pp. [Conference contribution]

Zhang, Huaizhong, Rodriguez, E. Patricia, Morrow, Philip, McClean, Sally and Saetzler, Kurt (2009) MCMC-based algorithm to adjust scale bias in large series of electron microscopical ultrathin sections. In: Proceedings of the 13th International Conference on Computer Analysis of Images and Patterns. UNSPECIFIED. 8 pp. [Conference contribution]

Ma, Y.L., Rhode, K.S., Razavi, R. and Saetzler, Kurt (2008) Real-Time Visualization of Cardiac Catheterization Procedures Based on a New Algorithm for Reconstructions from Planar Cross Sections Using the Unconstrained 3D Delaunay Triangulation. In: Proc. International Machine Vision and Image Processing Conference IMVIP '08, Coleraine. UNSPECIFIED. 6 pp. [Conference contribution]

Ma, Ying Liang, Rhode, Kawal S., King, Andy P., Phani Chinchapatnam, Gang Gao, Schaeffter, Tobias, Razavi, Reza and Saetzler, Kurt (2008) Time-varying Image Data Visualization Framework for Application in Cardiac Catheterization Procedures. In: Theory and Practice of Computer Graphics, Manchester. UNSPECIFIED. 4 pp. [Conference contribution]

Zhang, Huaizhong, Morrow, PJ, McClean, S and Saetzler, Kurt (2008) Contour detection of labeled cellular structures from serial ultrathin electron microscopy sections using GAC and prior analysis. In: IEEE Proceedings of IPTA'08. UNSPECIFIED. 7 pp. [Conference contribution]

Bigot, S., Lucas, L., Morrow, PJ, Mitchell, Christopher and Saetzler, Kurt (2007) Estimating leukocyte velocities from high-speed 1D line scans oriented orthogonal to blood flow. In: Biomedical Imaging: Macro to Nano, 2007. 4rd IEEE International Symposium on, Washington. UNSPECIFIED. 4 pp. [Conference contribution]

Morrow, PJ and Saetzler, Kurt (2007) Validation of in vivo Leukocyte Velocity Estimates via Modeling and Simulation. In: Conference Record of the Forty-First Asilomar Conference on Signals, Systems and Computers ACSSC 2007, Pacific Groove. UNSPECIFIED. 5 pp. [Conference contribution]

Zhang, Huaizhong, Morrow, Philip, McClean, Sally and Saetzler, Kurt (2007) Incorporating Feature Based Priors into the Geodesic Active Contour Model and its Application in Biomedical Imagery. In: Proc. of the International Machine Vision and Image Processing Conference, 2007. IMVIP 2007.. UNSPECIFIED. 8 pp. [Conference contribution]

McEnery, O., Lucas, L., Ma, YingLiang, Morrow, PJ, Mitchell, Christopher and Saetzler, Kurt (2006) A fast, robust and scale-independent approach to estimate vessel diameters in intravital fluorescence microscopy images. In: Biomedical Imaging: Macro to Nano, 2006. 3rd IEEE International Symposium on. UNSPECIFIED. 4 pp. [Conference contribution]

Bornfleth, H., Zink, D., Saetzler, Kurt, Eils, R. and Cremer, C. (1996) Modellgestützte Segmentierung von Replikationsdomänen in dreidimensionalen konfokalen Mikroskopiebildern. In: Mustererkennung 1996. UNSPECIFIED. 12 pp. [Conference contribution]

Saetzler, Kurt, Cremer, Cornelius and Eils, Roland (1996) 3D-Bildfolgen zur Auflösungsverbesserung in der Fluoreszenzmikroskopie. In: Mustererkennung 1996, 18. DAGM-Symposium. UNSPECIFIED. 16 pp. [Conference contribution]

Eils, R., Saracoglu, K., Münkel, C., Imhoff, J., Saetzler, Kurt, Dietzel, S., Schröck, E., Ried, T., Cremer, T. and Cremer, C. (1995) Three--dimensional imaging approaches and Monte Carlo simulations: development of tools to study the morphology and distribution of chromosome territories and subchromosomal targets in human cell nuclei. In: Zoological Studies. UNSPECIFIED. 4 pp. [Conference contribution]

Journal article

faivre, Emilie, Gault, Victor, thorens, Bernard and Holscher, Christian (2011) Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis. J Neurophysiol, 89 . pp. 481-489. [Journal article]

Hamilton, Alison, Patterson, Steven, porter, David, Gault, Victor A and Holscher, Christian (2011) Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. J Neurosci Res, 89 . pp. 481-489. [Journal article]

McClean, Paula, Parthsarathy, Vadivel, Faivre, Emilie and Holscher, Christian (2011) The diabetes drug Liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. The Journal of Neuroscience, 31 (17). pp. 6587-6594. [Journal article]

Fendt, M, Bürki, H, Imobersteg, S, van der Putten, H, McAllister, K, Leslie, Julian, Shaw, D and Holscher, Christian (2010) The effect of mGlu(8) deficiency in animal models of psychiatric diseases. Genes, brain, and behavior, 9 . pp. 33-44. [Journal article]

Gengler, Simon, Hamilton, Alison and Holscher, Christian (2010) Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer’s disease is impaired in old but not young mice. PLoS ONE, 000 . [Journal article]

Gengler, Simon, McClean, Paula, McCurtin, Ruth, Gault, Victor and Holscher, Christian (2010) Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol Aging, 000 . 000-000. [Journal article]

Holscher, Christian (2010) Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease. Recent Patents on CNS Drug Discovery, 5 . pp. 109-117. [Journal article]

Holscher, Christian and Li, Lin (2010) New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer’s Disease? Neurobiol Aging, 31 (9). pp. 1495-1502. [Journal article]

Hunter, Kerry, O'Harte, FPM, Abdel-Wahab, YHA and Flatt, PR (2010) Evaluation of the inhibitory action of islet amyloid polypeptide on insulin secretion from clonal rat pancreatic beta-cells. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). p. 44. [Journal article]

Irwin, Nigel, Porter, W. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Prolonged GIP receptor activation improves glucose homeostasis and cognitive function in high-fat fed mice. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). p. 44. [Journal article]

McArt, DG, McKerr, George, Saetzler, Kurt, Howard, Vyvyan, Downes, Stephen and Wasson, GR (2010) Comet sensitivity in assessing DNA damage and repair in different cell cycle stages. Mutagenesis, 25 (3). p. 299. [Journal article]

McClean, Paula, Gault, Victor A, Harriott, Patrick and Holscher, Christian (2010) Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease. EUROPEAN JOURNAL OF PHARMACOLOGY, 630 (1-3). pp. 158-162. [Journal article]

McClean, Paula, Parthsarathy, V., Faivre, E. and Holscher, Christian (2010) The novel GLP-1 analogue liraglutide has neuroprotective properties in a mouse model of Alzheimer's disease. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). p. 40. [Journal article]

Porter, D. W., Kerr, B. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance. DIABETES OBESITY & METABOLISM, 12 (10). pp. 891-899. [Journal article]

Porter, David, Irwin, Nigel, Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high fat fed mice. Eur J Pharmacol, 650 . pp. 688-693. [Journal article]

Porter, W. D., Kerr, B. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) The glucagon-like peptide-1 agonist Liraglutide improves memory and learning in obese-diabetic mice. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). p. 40. [Journal article]

Wang, xiao-Hui, li, Lin, Holscher, Christian, Pan, Yan-Fang, Chen, Xiao-Rong and Qi, Jin-Shun (2010) Val8-GLP-1 Protects Against Aß1-40-Induced Impairment of Hippocampal Late-Phase Long-Term Potentiation and Spatial Learning in Rats. Neuroscience, 170 . pp. 1239-1248. [Journal article]

Abbas, Talib, Faivre, Emilie and Holscher, Christian (2009) Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease. Behavioural brain research, 205 (1). pp. 265-71. [Journal article]

Hamilton, Alison and Holscher, Christian (2009) Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system. Neuroreport, 20 . pp. 1161-1166. [Journal article]

Holscher, Christian, Fung, K., McCurtin, R., Gault, Victor and McClean, Paula (2009) Novel GLP-1 analogues cross the blood brain barrier and enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease. DIABETOLOGIA, 52 (Suppl. 1). p. 790. [Journal article]

Li, Lin, Li, Yan-wei, Zhao, Jin-ying, Liu, Yue-Ze and Holscher, Christian (2009) Quantitative analysis of iron concentration and expression of ferroportin 1 in the cortex and hippocampus of rats induced by cerebral ischemia. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 16 (11). pp. 1466-72. [Journal article]

McArt, Darragh G, McKerr, G, Howard, Vyvyan, Saetzler, Kurt and Wasson, Gillian R (2009) Modelling the comet assay. Biochemical Society Transactions, 037 (4). pp. 914-917. [Journal article]

McClean, Paula, Gault, Victor, Harriott, Patrick and Holscher, Christian (2009) Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease. European journal of pharmacology, epub . [Journal article]

Wang, Hongjuan, Wang, Rong, Zhao, Zhiwei, Ji, Zhijuan, Xu, Shiming, Holscher, Christian and Sheng, Shuli (2009) Coexistences of insulin signaling-related proteins and choline acetyltransferase in neurons. Brain research, 1249 . pp. 237-43. [Journal article]

Gault, Victor and Holscher, Christian (2008) GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid. European journal of pharmacology, 587 (1-3). pp. 112-7. [Journal article]

Gault, Victor A and Holscher, Christian (2008) Protease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid. Journal of neurophysiology, 99 (4). pp. 1590-5. [Journal article]

Guerreiro-Lucas, Luciano A, Pop, S. Rares, Ma, Maria J C Machado and Ying Liang, Waters, Sarah L, Richardson, Giles, Saetzler, Kurt, Jensen, Oliver E and Mitchell, Christopher (2008) Experimental and theoretical modelling of blind-ended vessels within a developing angiogenic plexus. Microvasc Res, 76 . pp. 161-168. [Journal article]

Holscher, Christian and Li, Lin (2008) New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimer's disease? Neurobiology of Aging, epub . [Journal article]

Holscher, Christian, van Aalten, Lidy and Sutherland, Calum (2008) Anaesthesia generates neuronal insulin resistance by inducing hypothermia. BMC neuroscience, 9 . p. 100. [Journal article]

Ma, YingLiang and Saetzler, Kurt (2008) A Parallelized Surface Extraction Algorithm for Large Binary Image Data Sets Based on an Adaptive 3-D Delaunay Subdivision Strategy. IEEE Transactions on Visualization and Computer Graphics, 14 (1). pp. 160-172. [Journal article]

Gengler, Simon, Gault, Victor, Harriott, Peter and Holscher, Christian (2007) Beta-amyloid (25-35) induced impairments of hippocampal synaptic plasticity are dependent on stimulation-protocol, genetic background, and aggregation state. Exp Brain Res, 179 . pp. 621-632. [Journal article]

Li, Lin and Holscher, Christian (2007) Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain research reviews, 56 (2). pp. 384-402. [Journal article]

Rollenhagen, Astrid, Saetzler, Kurt, Rodriguez, Peter, Frotscher, Michael and Lübke, Joachim H. R. (2007) Structural Determinants of Transmission at Large Hippocampal Mossy Fiber Synapses. J. Neurosci., 27 (39). pp. 10434-10444. [Journal article]

Radde, R, Bolmont, T, Käser, SA, Coomaraswamy, J, Lindau, D, Stoltze, L, Calhoun, ME, Jäggi, F, Wolburg, H, Gengler, S, Haass, C, Ghetti, B, Czech, C, Holscher, Christian, Mathews, PM and Jucker, M (2006) Aß42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Reports, 7 . pp. 940-946. [Journal article]

Holscher, Christian (2005) Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies. Reviews in the Neurosciences, 16 . pp. 181-212. [Journal article]

Holscher, Christian, Schmid, S, Pilz, P, van der Putten, H and Plappert, C (2005) Lack of the metabotropic glutamate receptor subtype 7 selectively modulates theta rhythm and working memory. Learning and Memory, 12 . pp. 450-455. [Journal article]

Saetzler, Kurt, Söhl, Leander F, Bollmann, Johann H, Borst, J. Gerard G, Frotscher, Michael, Sakmann, Bert and Lübke, Joachim H R (2002) Three-dimensional reconstruction of a calyx of Held and its postsynaptic principal neuron in the medial nucleus of the trapezoid body. J Neurosci, 22 (24). pp. 10567-10579. [Journal article]

Grabenbauer, M., Saetzler, Kurt, Baumgart, E. and Fahimi, H.D. (2000) Three-dimensional ultrastructural analysis of peroxisomes in HepG2 cells: Absence of a peroxisomal reticulum but evidence of close spatial association with the endoplasmic reticulum. Cell. Biochem. Biophys., 32 . pp. 37-49. [Journal article]

Bornfleth, H., Saetzler, Kurt, Elis, R. and Cremer, C. (1998) High-precision distance measurements and volume-conserving segmentation of objects near and below the resolution limit in three-dimensional confocal fluorescence microscopy. Journal of Microscopy, 189 . pp. 118-136. [Journal article]

Dietzel, S., Eils, R., Saetzler, Kurt, Bornfeld, H., Jauch, A., Cremer, C. and Cremer, T. (1998) Evidence against a looped structure of the inactive human X--chromosome territory. Exp. Cell Res, 240 (2). pp. 187-196. [Journal article]

Eils, R., Uhrig, S., Saetzler, Kurt, Saracoglu, K., Chassery, A. Bolzer and J.-M., Ganser, M. and Speicher, M.R. (1998) An optimized and fully automated system for fast and accurate identification of chromosomal rearrangements my multiplex-FISH (M-FISH). Cell Genetics and Cytogenetics, 82 . pp. 160-171. [Journal article]

Saetzler, Kurt and Eils, R. (1997) Resolution improvement by 3-D reconstructions from tilted views in axial tomography and confocal theta microscopy. Bioimaging, 5 . pp. 171-182. [Journal article]

Other

Saetzler, Kurt (2000) 3D Rekonstruktion von Serienschnitten mit CAR. [Other]

Saetzler, Kurt (2000) 3D--Rekonstruktion von elektronenmikroskopischen Serienschnitten. [Other] (Unpublished)

Thesis

[Thesis]

This list was generated on Thu Jul 24 03:56:08 2014 BST.