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Number of items: 101.

2013

Vasu, S, McClenaghan, Neville, McCluskey, Janie and Flatt, Peter (2013) Cellular responses of novel human pancreatic β-cell line, 1.1B4 to hyperglycemia. Islets, 5 (4). 0-0. [Journal article]

Vasu, S, McClenaghan, Neville, McCluskey, Janie and Flatt, Peter (2013) Effects of lipotoxicity on novel insulin secreting human pancreatic β-cell line, 1.1B4. Biological Chemistry, 394 (7). pp. 909-918. [Journal article]

Vasu, Srividya, McClenaghan, Neville, McCluskey, Janie and Flatt, Peter (2013) Mechanisms of toxicity by proinflammatory cytokines in a novel human pancreatic beta cell line, 1.1B4. Biochimica et Biophysica Acta , 1840 (1). pp. 136-145. [Journal article]

2012

Abed, Arif, Critchlow, Charlotte, Flatt, Peter, McClenaghan, Neville and Kelly, Catriona (2012) Directed differentiation of progenitor cells towards an islet-cell phenotype. Am J Stem Cells., 1(3) . pp. 196-204. [Journal article]

da Silva Krause , M, Bittencourt , A, Homem de Bittencourt , PI jr, McClenaghan, Neville, Flatt, Peter, Murphy , C and Newsholme , P (2012) Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic β-cell line and mouse islets. Journal of Endocrinology, 214 (3). pp. 301-311. [Journal article]

Guo-Parke, H, McCluskey, Janie, Kelly , C, Hamid , M, McClenaghan, Neville and Flatt, Peter (2012) Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility. Journal of Endocrinology , 214 (3). pp. 257-265. [Journal article]

Guo-Parke, H., McCluskey, Janie, Kelly, Catriona, Hamid, M., McClenaghan, Neville and Flatt, Peter (2012) Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility. Journal of Endocrinology, 214 (3). p. 257. [Journal article]

McClenaghan, Neville, Flatt, Peter, Harper, AGS and Kelly, Catriona (2012) Establishment of an F508del pseudoislet model for the study of CF-related diabetes. Journal of Cystic Fibrosis, 11 . S117. [Journal article]

Scullion, S. M. J., Gurgul-Convey, E., Elsner, M., Lenzen, S., Flatt, Peter and McClenaghan, Neville (2012) Enhancement of homocysteine toxicity to insulin-secreting BRIN-BD11 cells in combination with alloxan. JOURNAL OF ENDOCRINOLOGY, 214 (2). pp. 233-238. [Journal article]

2011

Irwin, Nigel, McKinney, J. M., Bailey, C. J., McClenaghan, Neville and Flatt, Peter (2011) Acute and Long-term Effects of Peroxisome Proliferator-activated Receptor-gamma Activation on the Function and Insulin Secretory Responsiveness of Clonal Beta-Cells. HORMONE AND METABOLIC RESEARCH, 43 (4). pp. 244-249. [Journal article]

Kelly, Catriona, Flatt, Cara C. S. and McClenaghan, Neville (2011) Stem Cell-Based Approaches for the Treatment of Diabetes. Stem Cells International, 2011 . p. 1. [Journal article]

Kelly, Catriona, McClenaghan, Neville and Flatt, Peter (2011) Role of islet structure and cellular interactions in the control of insulin secretion. Islets. , 3(2) . pp. 41-47. [Journal article]

Kelly, Catriona, McClenaghan, Neville H. and Flatt, Peter (2011) Role of islet structure and cellular interactions in the control of insulin secretion. ISLETS, 3 (2). pp. 41-47. [Journal article]

Krause, MS, McClenaghan, Neville, Flatt, Peter, de Bittencourt, PIH, Murphy, C and Newsholme, P (2011) L-Arginine is essential for pancreatic beta-cell functional integrity, metabolism and defense from inflammatory challenge. JOURNAL OF ENDOCRINOLOGY, 211 (1). pp. 87-97. [Journal article]

McCluskey, Janie, Hamid, Muhajir, Guo-Parke, Hong, McClenaghan, Neville, Gomis, Ramon and Flatt, Peter (2011) Development and Functional Characterization of Insulin-releasing Human Pancreatic Beta Cell Lines Produced by Electrofusion. JOURNAL OF BIOLOGICAL CHEMISTRY, 286 (25). pp. 21982-21992. [Journal article]

2010

Irwin, Nigel, McKinney, J. M., Bailey, C. J., Flatt, Peter and McClenaghan, Neville (2010) Effects of metformin on BRIN-BD11 beta-cell insulin secretory desensitization induced by prolonged exposure to sulphonylureas. DIABETES OBESITY & METABOLISM, 12 (12). pp. 1066-1071. [Journal article]

Kelly, C., Parke, H. Guo, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2010) Evaluation of role of islet cell paracrine interactions in regulation of insulin secretion using a new heterotypic pseudoislet model. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). p. 33. [Journal article]

Kelly, Catriona, Flatt, Peter and McClenaghan, Neville (2010) Cell-to-cell communication and cellular environment alter the somatostatin status of delta cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 399 (2). pp. 162-166. [Journal article]

Kelly, Catriona, Flatt, Peter and McClenaghan, Neville (2010) Cell-to-cell communication and cellular environment alter the somatostatin status of delta cells. Biochemical and Biophysical Research Communications, 399 (2). p. 162. [Journal article]

Kelly, Catriona, Guo, Hong, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2010) Comparison of Insulin Release From MIN6 Pseudoislets and Pancreatic Islets of Langerhans Reveals Importance of Homotypic Cell Interactions. PANCREAS, 39 (7). pp. 1016-1023. [Journal article]

Kelly, Catriona, Guo, Hong, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2010) Comparison of Insulin Release From MIN6 Pseudoislets and Pancreatic Islets of Langerhans Reveals Importance of Homotypic Cell Interactions. Pancreas, 39 (7). p. 1016. [Journal article]

Kelly, Catriona, Parke, Hong Guo, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2010) The role of glucagon- and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets. DIABETES-METABOLISM RESEARCH AND REVIEWS, 26 (7). pp. 525-533. [Journal article]

Kelly, Catriona, Parke, Hong Guo, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2010) The role of glucagon- and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets. Diabetes/Metabolism Research and Reviews, 26 (7). p. 525. [Journal article]

McKiney, Joan M., Irwin, Nigel, Flatt, Peter, Bailey, Clifford J. and McClenaghan, Neville (2010) Acute and long-term effects of metformin on the function and insulin secretory responsiveness of clonal beta-cells. BIOLOGICAL CHEMISTRY, 391 (12). pp. 1451-1459. [Journal article]

Persaud , SJ, Arden, C, Bergsten, P, Bone , AJ, Brown, J, Dunmore, S, Harrison, M, Hauge-Evans, A, Kelly, Catriona, King , A, Maffucci , T, Marriott , CE, McClenaghan, Neville, Morgan, N, Reers, C, Russell, MA, Turner, MD, Willoughby, E, Younis , MY, Zhi, ZL and Jones, PM (2010) Pseudoislets as primary islet replacements for research: report on a symposium at King's College London, London UK. Islets. 2010 Jul-Aug;2(4):236-9., 2(4) . pp. 236-239. [Journal article]

2009

Bender, Katrin, Maechler, Pierre, McClenaghan, Neville H., Flatt, Peter and Newsholme, Philip (2009) Overexpression of the malate-aspartate NADH shuttle member Aralar 1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism. CLINICAL SCIENCE, 117 (9-10). pp. 321-330. [Journal article]

Kiely A, A, Robinson A, A, McClenaghan, Neville H., Flatt, Peter and Newsholme P, P (2009) Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 beta-cell insulin secretion and signal transduction. Journal of Endocrinology, 202 (3). pp. 365-373. [Journal article]

McClenaghan, Neville, Scullion, Siobhan M., Mion, Brian, Hewage, Chandralal, Malthouse, J. Paul G., Flatt, Peter, Newsholme, Philip and Brennan, Lorraine (2009) Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic beta-cells. CLINICAL SCIENCE, 116 (3-4). pp. 341-351. [Journal article]

2008

Liu, Hui-Kang, McCluskey, Janie, McClenaghan, Neville and Flatt, Peter (2008) Iterative exposure of clonal BRIN-BD11 cells to ninhydrin enables selection of robust toxin-resistant cells but with decreased gene expression of insulin secretory function. PANCREAS, 36 (3). pp. 294-301. [Journal article]

2007

Brennan, L., Scullion, S. M., Mion, B., Hewage, C., Malthouse, J. P. G., Flatt, Peter, Newsholme, P. and McClenaghan, Neville H. (2007) Prolonged alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic beta cells. DIABETOLOGIA, 50 (Suppl. 1). 0509. [Journal article]

Kiely, Aoife, McClenaghan, Neville, Flatt, Peter and Newsholme, Philip (2007) Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic beta-cell line. JOURNAL OF ENDOCRINOLOGY, 195 (1). pp. 113-123. [Journal article]

Liu, Hui-Kang, McCluskey, Janie, McClenaghan, Neville and Flatt, Peter (2007) Streptozotocin-resistant BRIN-BD11 cells possess wide spectrum of toxin tolerance and enhanced insulin-secretory capacity. ENDOCRINE, 32 (1). pp. 20-29. [Journal article]

Patterson, Steven, Flatt, Peter and McClenaghan, Neville (2007) Homocysteine-induced impairment of insulin secretion from clonal pancreatic BRIN-BD11 beta-cells is not prevented by catalase. PANCREAS, 34 (1). pp. 144-151. [Journal article]

Patterson, Steven, Flatt, Peter and McClenaghan, Neville (2007) Major metabolic homocysteine-derivative, homocysteine thiolactone, exerts changes in pancreatic beta-cell glucose-sensing, cellular signal transduction and integrity. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 461 (2). pp. 287-293. [Journal article]

Patterson, Steven, Scullion, Siobhan M. J., McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2007) Prolonged exposure to homocysteine results in diminished but reversible pancreatic beta-cell responsiveness to insulinotropic agents. DIABETES-METABOLISM RESEARCH AND REVIEWS, 23 (4). pp. 324-334. [Journal article]

2006

Brennan, Lorraine, Hewage, Chandralal, Malthouse, J. P. G., McClenaghan, Neville, Flatt, Peter and Newsholme, Philip (2006) Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism. FEBS JOURNAL, 273 (22). pp. 5160-5168. [Journal article]

Corless, Mary, Kiely, Aoife, McClenaghan, Neville, Flatt, Peter and Newsholme, Philip (2006) Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene, and protein expression in a clonal pancreatic beta-cell line. JOURNAL OF ENDOCRINOLOGY, 190 (3). pp. 719-727. [Journal article]

Liu, Hui-Kang, Green, Brian D., McClenaghan, Neville, McCluskey, Janie and Flatt, Peter (2006) Deleterious effects of supplementation with dehydroepiandrosterone sulphate or dexamethasone on rat insulin-secreting cells under in vitro culture condition. BIOSCIENCE REPORTS, 26 (1). pp. 31-38. [Journal article]

Marenah, Lamin, McCluskey, Janie, Abdel-Wahab, Yasser, O'Harte, Finbarr, McClenaghan, Neville and Flatt, Peter (2006) A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL(16)), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones. BIOLOGICAL CHEMISTRY, 387 (7). pp. 941-947. [Journal article]

McClenaghan, Neville, Flatt, Peter and Ball, Andrew J. (2006) Actions of glucagon-like peptide-1 on K-ATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide. JOURNAL OF ENDOCRINOLOGY, 190 (3). pp. 889-896. [Journal article]

Patterson, Steven, Flatt, Peter, Brennan, L., Newsholme, P. and McClenaghan, Neville (2006) Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion. JOURNAL OF ENDOCRINOLOGY, 189 (2). pp. 301-310. [Journal article]

Patterson, Steven, Flatt, Peter and McClenaghan, Neville (2006) Homocysteine and other structurally-diverse amino thiols can alter pancreatic beta cell function without evoking cellular damage. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1760 (7). pp. 1109-1114. [Journal article]

2005

Ball, AJ, Flatt, Peter and McClenaghan, Neville (2005) Alterations of insulin secretion following long-term manipulation of ATP-sensitive potassium channels by diazoxide and nateglinide. BIOCHEMICAL PHARMACOLOGY, 69 (1). pp. 59-63. [Journal article]

Brennan, L, Hewage, C, Malthouse, JG, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2005) Effects of anti-diabetic drugs on beta cell glucose metabolism in a clonal cell line, BRIN-BD11. DIABETOLOGIA, 48 (Suppl. 1). p. 439. [Journal article]

Cunningham, GA, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2005) L-alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic beta-cell line and protects from pro-inflammatory cytokine-induced apoptosis. CLINICAL SCIENCE, 109 (5). pp. 447-455. [Journal article]

Green, BD, Liu, HK, McCluskey, Janie, Duffy, NA, O'Harte, Finbarr, McClenaghan, Neville and Flatt, Peter (2005) Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of GLP-1. DIABETES OBESITY AND METABOLISM, 7 (5). pp. 563-569. [Journal article]

2004

Ball, AJ, Flatt, Peter and McClenaghan, Neville (2004) Acute and long-term effects of nateglinide on insulin secretory pathways. BRITISH JOURNAL OF PHARMACOLOGY, 142 (2). pp. 367-373. [Journal article]

Ball, AJ, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2004) Chronic exposure to tolbutamide and glibenclamide impairs insulin secretion but not transcription of K-ATP channel components. PHARMACOLOGICAL RESEARCH, 50 (1). pp. 41-46. [Journal article]

Dixon, G, Nolan, J, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2004) Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity. CLINICAL SCIENCE, 106 (2). pp. 191-199. [Journal article]

Liu, HK, Green, BD, Flatt, Peter, McClenaghan, Neville and McCluskey, Janie (2004) Effects of long-term exposure to nicotinamide and sodium butyrate on growth, viability, and the function of clonal insulin secreting cells. ENDOCRINE RESEARCH, 30 (1). pp. 61-68. [Journal article]

Liu, HK, Green, BD, Gault, Victor, McCluskey, Janie, McClenaghan, Neville, O'Harte, Finbarr and Flatt, Peter (2004) N-acetyl-GLP-1: a DPP IV-resistant analogue of glucagon-like peptide-1 (GLP-1) with improved effects on pancreatic beta-cell-associated gene expression. CELL BIOLOGY INTERNATIONAL, 28 (1). pp. 69-73. [Journal article]

Liu, HK, Green, BD, McClenaghan, Neville, McCluskey, Janie and Flatt, Peter (2004) Long-term beneficial effects of vanadate, tungstate, and molybdate on insulin secretion and function of cultured beta cells. PANCREAS, 28 (4). pp. 364-368. [Journal article]

McClenaghan, Neville, McCluskey, Janie, Flatt, Peter and Patterson, Steven (2004) Homocysteine, a metabolic syndrome risk factor, exerts detrimental effects on insulin secretion and pancreatic beta cell function. DIABETOLOGIA, 47 (Suppl. 1). p. 466. [Journal article]

2003

Brennan, L, Corless, M, Hewage, C, Malthouse, JPG, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2003) C-13 NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line. DIABETOLOGIA, 46 (11). pp. 1512-1521. [Journal article]

Dixon, G, Nolan, J, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2003) A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11 - the functional significance of L-alanine. JOURNAL OF ENDOCRINOLOGY, 179 (3). pp. 447-454. [Journal article]

Irwin, Nigel, Green, BD, Lui, HK, McCluskey, Janie, McClenaghan, Neville, Gault, Victor, Harriott, P, Greer, B, O'Harte, Finbarr and Flatt, Peter (2003) Dipeptidylpeptidase IV-resistant glucagon-like peptide-1(7-36)amide analogue N-acetyl-GLP-1 has improved effects on pancreatic beta-cell associated gene expression. Irish Journal of Medical Science, 172 (S1) . p. 24. [Journal article]

2002

Brennan, L, Shine, A, Hewage, C, Malthouse, JPG, Brindle, KM, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2002) A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line - Metabolism of L-alanine is important to the regulation of insulin secretion. DIABETES, 51 (6). pp. 1714-1721. [Journal article]

Conroy, SJ, Green, I, Dixon, G, Byrne, PM, Nolan, J, Abdel-Wahab, Yasser, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2002) Evidence for a sustained increase in clonal beta-cell basal intracellular Ca2+ levels after incubation in the presence of newly diagnosed type-1 diabetic patient sera. Possible role in serum-induced inhibition of insulin secretion. JOURNAL OF ENDOCRINOLOGY, 173 (1). pp. 53-62. [Journal article]

Hamid, M, McCluskey, Janie, McClenaghan, Neville and Flatt, Peter (2002) Comparison of the secretory properties of four insulin-secreting cell lines. ENDOCRINE RESEARCH, 28 (1-2). pp. 35-47. [Journal article]

Picton, SF, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2002) Effects of cytotoxic agents on functional integrity and antioxidant enzymes in clonal beta-cells. DIABETES AND METABOLISM, 28 (6, Part 2). S70-S77. [Journal article]

2001

Brennan, L, Shine, A, Hewage, C, Brindle, KM, Malthouse, JPG, McClenaghan, Neville, Flatt, Peter and Newsholme, P (2001) A NMR study of glucose and alanine metabolism by the beta cell lines RINm5F and BRIN-BD11. DIABETOLOGIA, 44 (Suppl. 1). p. 472. [Journal article]

Hamid, M, McCluskey, Janie, McClenaghan, Neville and Flatt, Peter (2001) Comparative functional study of clonal insulin-secreting cells cultured in five commercially available tissue culture media. CELL TRANSPLANTATION, 10 (2). pp. 153-159. [Journal article]

Hamid, M, McCluskey, Janie, McClenaghan, Neville and Flatt, Peter (2001) Functional examination of microencapsulated bioengineered insulin-secreting beta-cells. CELL BIOLOGY INTERNATIONAL, 25 (6). pp. 553-556. [Journal article]

McClenaghan, Neville, Ball, AJ and Flatt, Peter (2001) Nateglinide exhibits glucose-sensitive K-ATP channel-dependent and independent insulinotropic actions. DIABETOLOGIA, 44 (Suppl. 1). p. 824. [Journal article]

McClenaghan, Neville, Ball, AJ and Flatt, Peter (2001) Specific desensitization of sulfonylurea- but not imidazoline-induced insulin release after prolonged tolbutamide exposure. BIOCHEMICAL PHARMACOLOGY, 61 (5). pp. 527-536. [Journal article]

2000

Ball, AJ, Flatt, Peter and McClenaghan, Neville (2000) Desensitization of sulphonylurea- and nutrient-induced insulin secretion following prolonged treatment with glibenclamide. EUROPEAN JOURNAL OF PHARMACOLOGY, 408 (3). pp. 327-333. [Journal article]

Ball, AJ, Flatt, Peter and McClenaghan, Neville (2000) Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14R and RX801080. PHARMACOLOGICAL RESEARCH, 42 (6). pp. 575-579. [Journal article]

Ball, AJ, McCluskey, Janie, Flatt, Peter and McClenaghan, Neville (2000) Drug-induced desensitization of insulinotropic actions of sulfonylureas. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 271 (1). pp. 234-239. [Journal article]

Flatt, Peter, Ball, AJ and McClenaghan, Neville (2000) GLP-1(7-36)amide enhances K-ATP channel-dependent and -independent insulinotropic actions of sulphonylureas. DIABETOLOGIA, 43 (Suppl. 1). p. 119. [Journal article]

Hamid, M, McCluskey, Janie, McClenaghan, Neville and Flatt, Peter (2000) Culture and function of electrofusion-derived clonal insulin-secreting cells immobilized on solid and macroporous microcarrier beads. BIOSCIENCE REPORTS, 20 (3). pp. 167-176. [Journal article]

McClenaghan, Neville, Ball, AJ and Flatt, Peter (2000) Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide. BRITISH JOURNAL OF PHARMACOLOGY, 130 (2). pp. 478-484. [Journal article]

McClenaghan, Neville and Flatt, Peter (2000) Metabolic and K-ATP channel-independent actions of keto acid initiators of insulin secretion. PANCREAS, 20 (1). pp. 38-46. [Journal article]

1999

Ball, AJ, Flatt, Peter and McClenaghan, Neville (1999) BTS 67 582 has common and distinct beta cell actions to sulphonylurea and imidazoline drugs. DIABETOLOGIA, 42 (Suppl. 1). p. 919. [Journal article]

Chapman, JC, McClenaghan, Neville, Cosgrove, KE, Hashmi, MN, Shepherd, RM, Giesberts, AN, White, SJ, Ammala, C, Flatt, Peter and Dunne, MJ (1999) ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line. DIABETES, 48 (12). pp. 2349-2357. [Journal article]

Dunne, MJ, Chapman, JC, McClenaghan, Neville, Hashmi, MN, Shepherd, RM, Cosgrove, KE, Giesberts, AN, White, SJ and Flatt, Peter (1999) The imidazoline efaroxan influences SUR1 protein expression in insulin-secreting cells. DIABETOLOGIA, 42 (Suppl. 1). p. 483. [Journal article]

McClenaghan, Neville, Ball, AJ and Flatt, Peter (1999) Downregulation of K-ATP-channel-dependent and -independent insulinotropic actions of tolbutamide. DIABETOLOGIA, 42 (Suppl. 1). p. 479. [Journal article]

McClenaghan, Neville and Flatt, Peter (1999) Engineering cultured insulin-secreting pancreatic B-cell lines. JOURNAL OF MOLECULAR MEDICINE-JMM, 77 (1). pp. 235-243. [Journal article]

McClenaghan, Neville and Flatt, Peter (1999) Glucose and non-glucidic nutrients exert permissive effects on 2-keto acid regulation of pancreatic beta-cell function. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1426 (1). pp. 110-118. [Journal article]

McClenaghan, Neville and Flatt, Peter (1999) Physiological and pharmacological regulation of insulin release: insights offered through exploitation of insulin-secreting cell lines. DIABETES OBESITYAND METABOLISM, 1 (3). pp. 137-150. [Journal article]

1998

McClenaghan, Neville, Barnett, CR and Flatt, Peter (1998) Na+ cotransport by metabolizable and nonmetabolizable amino acids stimulates a glucose-regulated insulin-secretory response. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 249 (2). pp. 299-303. [Journal article]

McClenaghan, Neville and Flatt, Peter (1998) Metabolic and K+-ATP channel-independent secretory actions of glucose and 2-keto acids in clonal beta-cells. DIABETOLOGIA, 41 (Suppl. 1). p. 545. [Journal article]

McClenaghan, Neville, Flatt, Peter and Bailey, CJ (1998) Insulin-releasing action of the novel antidiabetic agent BTS 67 582. BRITISH JOURNAL OF PHARMACOLOGY, 123 (3). pp. 400-404. [Journal article]

1997

Chapman, JC, Cosgrove, K, McClenaghan, Neville, Ammala, C, Flatt, Peter and Dunne, MJ (1997) Properties of ion channels and the regulation of insulin secretion in the novel glucose-responsive beta-cell line, BRIN-BD11. DIABETOLOGIA, 40 (Suppl. 1). p. 390. [Journal article]

1996

Abdel-Wahab, Yasser, O'Harte, Finbarr, Ratcliff, H, McClenaghan, Neville, Barnett, CR and Flatt, Peter (1996) Glycation of insulin in the islets of Langerhans of normal and diabetic animals. DIABETES, 45 (11). pp. 1489-1496. [Journal article]

McClenaghan, Neville, Barnett, CR, AhSing, E, Abdel-Wahab, Yasser, O'Harte, Finbarr, Yoon, TW, SwanstonFlatt, SK and Flatt, Peter (1996) Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion. DIABETES, 45 (8). pp. 1132-1140. [Journal article]

McClenaghan, Neville, Barnett, CR, AhSing, E, SwanstonFlatt, SK and Flatt, Peter (1996) Secretory properties of clonal insulin-secreting BRIN-BG5 cells, produced by electrofusion. BIOCHEMICAL SOCIETY TRANSACTIONS, 24 (1). S101. [Journal article]

McClenaghan, Neville, Barnett, CR and Flatt, Peter (1996) Na+ involvement in glucose and neutral amino acid-induced insulin secretion. DIABETOLOGIA, 39 (Suppl. 1). p. 424. [Journal article]

McClenaghan, Neville, Barnett, CR, O'Harte, Finbarr and Flatt, Peter (1996) Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line. JOURNAL OF ENDOCRINOLOGY, 151 (3). pp. 349-357. [Journal article]

McClenaghan, Neville, Barnett, CR, O'Harte, Finbarr, SwanstonFlatt, SK, AhSing, E and Flatt, Peter (1996) Characteristics of BRIN-BG5 and BRIN-BG7, two novel glucose-responsive insulin-secreting cell lines produced by electrofusion. JOURNAL OF ENDOCRINOLOGY, 148 (3). pp. 409-417. [Journal article]

McClenaghan, Neville, Gallagher, Alison, Barnett, CR and Flatt, Peter (1996) Hexose recognition by insulin-secreting BRIN-BD11 cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 223 (3). pp. 724-728. [Journal article]

Rasschaert, J, Flatt, Peter, Barnett, CR, McClenaghan, Neville and Malaisse, WJ (1996) D-glucose metabolism in BRIN-BD11 islet cells. BIOCHEMICAL AND MOLECULAR MEDICINE, 57 (2). pp. 97-105. [Journal article]

Rasschaert, J, Flatt, Peter, McClenaghan, Neville and Malaisse, WJ (1996) Amino acid oxidation in BRIN-BD11 islet cells. MEDICAL SCIENCE RESEARCH, 24 (10). pp. 691-692. [Journal article]

1995

Barnett, CR, Clarke, J, McClenaghan, Neville and Flatt, Peter (1995) CYTOCHROME-P450 CYP1A EXPRESSION IN THE PANCREATIC-ISLETS OF LANGERHANS. DIABETOLOGIA, 38 (Suppl. 1). A135. [Journal article]

Clarke, J, McClenaghan, Neville, Barnett, CR, Ahsing, E, Yoon, TW, Swanstonflatt, SK and Flatt, Peter (1995) BRIN-BG7, A NOVEL GLUCOSE-RESPONSIVE INSULIN-SECRETING CELL-LINE PRODUCED BY ELECTROFUSION. DIABETOLOGIA, 38 (Suppl. 1). A108. [Journal article]

Flatt, Peter, O'Harte, Finbarr, Abdel-Wahab, Yasser, McClenaghan, Neville and Barrnett, CR (1995) GLYCATION OF INSULIN AND PROINSULIN OCCURS IN THE ISLETS OF LANGERHANS OF DIABETIC ANIMALS. DIABETOLOGIA, 38 (Suppl. 1). A92. [Journal article]

McClenaghan, Neville, Barnett, CR, Swanstonflatt, SK and Flatt, Peter (1995) COMPARISON OF THE GLUCOSE-SENSING ABILITY OF 3 NOVEL GLUCOSE-RESPONSIVE PANCREATIC B-CELL LINES. DIABETOLOGIA, 38 (Suppl. 1). A108. [Journal article]

1994

McClenaghan, Neville, Yoon, TW, Barnett, CR, Wilson, AM, Abdel-Wahab, Yasser, Swanstonflatt, S, Ahsing, E and Flatt, Peter (1994) EFFECT OF GLUCOSE AND AMINO-ACIDS ON INSULIN-SECRETION FROM A NOVEL PANCREATIC B-CELL LINE PRODUCED BY ELECTROFUSION. BIOCHEMICAL SOCIETY TRANSACTIONS, 22 (2). S237. [Journal article]

1993

Flatt, Peter, Yoon, TW, Barnett, CR, McClenaghan, Neville, Wilson, AM, Abdel-Wahab, Yasser, Ahsing, E and Swanstonflatt, SK (1993) PRODUCTION OF A NOVEL GLUCOSE-RESPONSIVE INSULIN-SECRETING PANCREATIC B-CELL LINE BY ELECTROFUSION. DIABETOLOGIA, 36 (Suppl. 1). A31. [Journal article]

1992

McClenaghan, Neville, BERTS, A, DRYSELIUS, S, THORELL, IM and HELLMAN, B (1992) NONMETABOLIZABLE ALPHA-AMINOISOBUTYRIC-ACID EVOKES A GLUCOSE-DEPENDENT INSULIN SECRETORY RESPONSE IN BETA-CELLS. DIABETOLOGIA, 35 (Suppl. 1). A113. [Journal article]

TENGHOLM, A, McClenaghan, Neville, GRAPENGIESSER, E, GYLFE, E and HELLMAN, B (1992) GLYCINE POTENTIATION OF INSULIN RELEASE INVOLVES NA+-DEPENDENT INCREASE OF CYTOPLASMIC CA2+. DIABETOLOGIA, 35 (Suppl. 1). A117. [Journal article]

TENGHOLM, A, McClenaghan, Neville, GRAPENGIESSER, E, GYLFE, E and HELLMAN, B (1992) GLYCINE TRANSFORMATION OF CA-2+ OSCILLATIONS INTO A SUSTAINED INCREASE PARALLELS POTENTIATION OF INSULIN RELEASE. BIOCHIMICA ET BIOPHYSICA ACTA, 1137 (3). pp. 243-247. [Journal article]

This list was generated on Thu Jul 31 07:49:03 2014 BST.