Ulster University Logo

Ulster Institutional Repository

Browse by Ulster Authors and Editors

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute
Up a level
Export as [feed] RSS 2.0 [feed] RSS 1.0 [feed] Atom
Group by: Date | Item Type | No Grouping
Jump to: 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 1999
Number of items: 151.

2014

Lennox, R, Porter, DW, Flatt, Peter, Holscher, C, Irwin, Nigel and Gault, Victor (2014) Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice. Neuropharmacology, 86C . pp. 22-30. [Journal article]

Lynch, AM, Patahk, P, Flatt, YE, Gault, Victor, O'Harte, Finbarr, Irwin, Nigel and Flatt, Peter (2014) Comparison of stability, cellular, glucose-lowering and appetite supressing effects of oxyntomodulin analogues modified at the N-terminus. European Journal of Pharmacology, 743 . pp. 69-78. [Journal article]

Lynch, AM, Pathak, N, Pathak, V, O'Harte, Finbarr, Flatt, Peter, Irwin, Nigel and Gault, Victor (2014) A novel DPP IV-resistant C-terminally extended glucagon analogue exhibits weight-lowering and diabetes-protective effects in high-fat-fed mice mediated through glucagon and GLP-1 receptor activation. Diabetologia, 57 (9). pp. 1927-1936. [Journal article]

Martin, CA, Parthsarathy, V, Pathak, V, Gault, Victor, Flatt, Peter and Irwin, Nigel (2014) Characterisation of the biological activity of xenin-25 degradation fragment peptides. Journal of Endocrinology, 221 (2). pp. 193-200. [Journal article]

2013

Bhat, VK, Kerr, BD, Flatt, Peter and Gault, Victor (2013) A novel GIP-Oxyntomodulin hybrid peptide acting through GIP, glucagon and GLP-1 receptors exhibits weight reducing and anti-diabetic properties. Biochemical Pharmacology, 85 (11). pp. 1655-1662. [Journal article]

Bhat, VK, Kerr, BD, Vasu, S, Flatt, Peter and Gault, Victor (2013) A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice. Diabetologia, 56 (6). pp. 1417-1424. [Journal article]

Gault, Victor, Bhat, VK, Irwin, Nigel and Flatt, Peter (2013) A novel GLP-1/glucagon hybrid peptide with triple-acting agonist activity at GIP, GLP-1 and glucagon receptors and therapeutic potential in high-fat fed mice. Journal of Biological Chemistry, 288 (49). pp. 35581-35591. [Journal article]

Irwin, Nigel and Gault, Victor (2013) Unraveling the mechanisms underlying olanzapine-induced insulin resistance. Diabetes, 62 (9). pp. 3022-3023. [Journal article]

Lennox, R, Porter, DW, Flatt, Peter and Gault, Victor (2013) (Val(8) )GLP-1-Glu-PAL: a GLP-1 Agonist That Improves Hippocampal Neurogenesis, Glucose Homeostasis, and β-Cell Function in High-Fat-Fed Mice. ChemMedChem, 8 (4). pp. 595-602. [Journal article]

Martin, CM, Irwin, Nigel, Flatt, Peter and Gault, Victor (2013) A novel acylated form of (d-Ala2)GIP with improved antidiabetic potential, lacking effect on body fat stores. Biochimica et Biophysica Acta, 1830 (6). pp. 3407-3413. [Journal article]

Porter, DW, Flatt, Peter, Holscher, Christian and Gault, Victor (2013) Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice. International Journal of Obesity, 37 (5). pp. 678-684. [Journal article]

2012

Gengler, Simon, McClean, Paula L., McCurtin, Ruth, Gault, Victor and Holscher, Christian (2012) Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. NEUROBIOLOGY OF AGING, 33 (2). pp. 265-276. [Journal article]

Martin, Christine M.A., Gault, Victor, McClean, Stephen, Flatt, Peter and Irwin, Nigel (2012) Degradation, insulin secretion, glucose-lowering and GIP additive actions of a palmitate-derivatised analogue of xenin-25. Biochemical Pharmacology, 84 (3). 312- 319. [Journal article]

Porter, David, Faivre, Emilie, Flatt, Peter, Holscher, Christian and Gault, Victor (2012) Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice. PEPTIDES, 35 (1). pp. 1-8. [Journal article]

2011

faivre, Emilie, Gault, Victor, thorens, Bernard and Holscher, Christian (2011) Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis. J Neurophysiol, 89 . pp. 481-489. [Journal article]

Gault, Victor, Kerr, Barry D., Harriott, Patrick and Flatt, Peter (2011) Administration of an acylated GLP-I and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with Type 2 diabetes and obesity. CLINICAL SCIENCE, 121 (3-4). pp. 107-117. [Journal article]

Gault, Victor, Porter, David W., Irwin, Nigel and Flatt, Peter (2011) Comparison of sub-chronic metabolic effects of stable forms of naturally occurring GIP(1-30) and GIP(1-42) in high-fat fed mice. JOURNAL OF ENDOCRINOLOGY, 208 (3). pp. 265-271. [Journal article]

Hamilton, Alison, Patterson, Steven, porter, David, Gault, Victor A and Holscher, Christian (2011) Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. J Neurosci Res, 89 . pp. 481-489. [Journal article]

Kerr, Barry D., Flatt, Anneliese J. S., Flatt, Peter and Gault, Victor (2011) Characterization and biological actions of N-terminal truncated forms of glucose-dependent insulinotropic polypeptide. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 404 (3). pp. 870-876. [Journal article]

McClean, P. L., Parthasarathy, V., Gault, Victor and Holscher, Christian (2011) LIRAGLUTIDE, A NOVEL GLP-1 ANALOGUE, PREVENTS THE IMPAIRMENT OF LEARNING AND LTP AND PLAQUE FORMATION IN AN APP/PS-1 MOUSE MODEL OF ALZHEIMER'S DISEASE. IRISH JOURNAL OF MEDICAL SCIENCE, 180 (2). p. 18. [Journal article]

2010

Gault, Victor, Kerr, B. D. and Flatt, Peter (2010) Improved glucose-lowering, insulin-releasing and anorexigenic actions of a novel chemically modified analogue of oxyntomodulin, (D-Ser(2))Oxm[mPEG-PAL]. DIABETOLOGIA, 53 (Suppl. 1). p. 20. [Journal article]

Gault, Victor, Kerr, B. D. and Flatt, Peter (2010) Investigating the role of the glutamyl linker on the biological efficacy of Liraglutide. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). pp. 44-45. [Journal article]

Gault, Victor, Porter, W. D., Flatt, Peter and Holscher, Christian (2010) Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet. INTERNATIONAL JOURNAL OF OBESITY, 34 (8). pp. 1341-1344. [Journal article]

Gengler, Simon, McClean, Paula, McCurtin, Ruth, Gault, Victor and Holscher, Christian (2010) Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol Aging, 000 . 000-000. [Journal article]

Irwin, Nigel, Gault, Victor and Flatt, Peter (2010) Therapeutic potential of the original incretin hormone glucose-dependent insulinotropic polypeptide: diabetes, obesity, osteoporosis and Alzheimer's disease? EXPERT OPINION ON INVESTIGATIONAL DRUGS, 19 (9). pp. 1039-1048. [Journal article]

Irwin, Nigel, Porter, W. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Prolonged GIP receptor activation improves glucose homeostasis and cognitive function in high-fat fed mice. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). p. 44. [Journal article]

Irwin, Nigel, Taylor, Ashley, Flatt, Peter and Gault, Victor (2010) Assessment of the metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satiety. DIABETOLOGIA, 53 (Suppl. 1). p. 22. [Journal article]

Kerr, B. D., Flatt, Peter and Gault, Victor (2010) A novel analogue of oxyntomodulin with improved glucose-lowering, insulinotropic and anorexigenic actions. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). p. 33. [Journal article]

Kerr, Barry D., Flatt, Peter and Gault, Victor (2010) (D-Ser(2))Oxm[mPEG-PAL]: A novel chemically modified analogue of oxyntomodulin with antihyperglycaemic, insulinotropic and anorexigenic actions. BIOCHEMICAL PHARMACOLOGY, 80 (11). pp. 1727-1735. [Journal article]

Kerr, Barry D., Flatt, Peter and Gault, Victor (2010) Effects of gamma-glutamyl linker on DPP-IV resistance, duration of action and biological efficacy of acylated glucagon-like peptide-1. BIOCHEMICAL PHARMACOLOGY, 80 (3). pp. 396-401. [Journal article]

McClean, Paula, Gault, Victor A, Harriott, Patrick and Holscher, Christian (2010) Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease. EUROPEAN JOURNAL OF PHARMACOLOGY, 630 (1-3). pp. 158-162. [Journal article]

Porter, D. W., Kerr, B. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance. DIABETES OBESITY & METABOLISM, 12 (10). pp. 891-899. [Journal article]

Porter, David, Irwin, Nigel, Flatt, Peter, Holscher, Christian and Gault, Victor (2010) Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high fat fed mice. Eur J Pharmacol, 650 . pp. 688-693. [Journal article]

Porter, W. D., Kerr, B. D., Flatt, Peter, Holscher, Christian and Gault, Victor (2010) The glucagon-like peptide-1 agonist Liraglutide improves memory and learning in obese-diabetic mice. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). p. 40. [Journal article]

Taylor, Ashley, Irwin, Nigel, McKillop, Aine, Flatt, Peter and Gault, Victor (2010) Xenin: An anorectic peptide involved in insulin secretion and glucose homeostasis. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). p. 41. [Journal article]

Taylor, Ashley, Irwin, Nigel, McKillop, Aine, Patterson, Steven, Flatt, Peter and Gault, Victor (2010) Evaluation of the degradation and metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satiety. JOURNAL OF ENDOCRINOLOGY, 207 (1). pp. 87-93. [Journal article]

2009

Gault, Victor, Kerr, BD, Irwin, Nigel, O'Harte, Finbarr and Flatt, Peter (2009) Fatty acid derivatised forms of glucose-dependent insulinotropic polypeptide with improved glucose-lowering and insulin-releasing properties. DIABETOLOGIA, 52 (Suppl. 1). p. 786. [Journal article]

Holscher, Christian, Fung, K., McCurtin, R., Gault, Victor and McClean, Paula (2009) Novel GLP-1 analogues cross the blood brain barrier and enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease. DIABETOLOGIA, 52 (Suppl. 1). p. 790. [Journal article]

Kerr, Barry D, Irwin, Nigel, O'Harte, Finbarr, Bailey, Clifford J, Flatt, Peter and Gault, Victor (2009) Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. BIOCHEMICAL PHARMACOLOGY, 78 (8). pp. 1008-1016. [Journal article]

Kerr, Barry D., Irwin, Nigel, Flatt, Peter and Gault, Victor (2009) Prolonged GIP receptor activation using stable mini-PEGylated GIP improves glucose homeostasis and beta-cell function in age-related glucose intolerance. PEPTIDES, 30 (2). pp. 219-225. [Journal article]

McClean, Paula, Gault, Victor, Harriott, Patrick and Holscher, Christian (2009) Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease. European journal of pharmacology, epub . [Journal article]

Moore, Sara, Smyth, Franklin, Gault, Victor, O'Kane, Edmund and McClean, Stephen (2009) Mass spectrometric characterisation and quantitation of selected low molecular mass compounds from the venom of Haplopelma lividum (Theraphosidae). RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 23 (12). pp. 1747-1755. [Journal article]

O'Harte, Finbarr, Kerr, BD, Irwin, Nigel, Gault, Victor and Flatt, Peter (2009) GIP(Lys37MYR), a novel acylated analogue of glucose-dependent insulinotropic polypeptide (GIP) has enhanced stability, glucose lowering and insulin releasing properties in obese diabetic (ob/ob) mice. Irish Journal of Medical Science, 178 (S10) . p. 389. [Journal article]

Taylor, AI, Frizzell, N, McKillop, Aine, Flatt, Peter and Gault, Victor (2009) Effect of RU486 on hepatic and adipocyte gene expression improves diabetes control in obesity-type 2 diabetes. Hormone Metabolic Research , 41 (12). pp. 899-904. [Journal article]

2008

Gault, Victor and Holscher, Christian (2008) GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid. European journal of pharmacology, 587 (1-3). pp. 112-7. [Journal article]

Gault, Victor, Kerr, Barry D., Irwin, Nigel and Flatt, Peter (2008) C-terminal mini-PEGylation of glucose-dependent insulinotropic polypeptide exhibits metabolic stability and improved glucose homeostasis in dietary-induced diabetes. BIOCHEMICAL PHARMACOLOGY, 75 (12). pp. 2325-2333. [Journal article]

Gault, Victor, Kerr, BD, Irwin, Nigel and Flatt, Peter (2008) Effects of C-terminal mini-PEGylation on metabolic stability and biological activity. Diabetic Medicine , 25 (S1) . p. 12. [Journal article]

Gault, Victor A and Holscher, Christian (2008) Protease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid. Journal of neurophysiology, 99 (4). pp. 1590-5. [Journal article]

Irwin, Nigel, Flatt, Peter and Gault, Victor (2008) GIP-based therapeutics for diabetes and obesity. Current Chemical Biology , 2 . pp. 61-68. [Journal article]

McClean, Paula, Gault, Victor, Irwin, Nigel, McCluskey, Janie and Flatt, Peter (2008) Daily administration of the GIP-R antagonist (Pro(3))GIP in streptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti-obesity-diabetes actions of (Pro(3))GIP. DIABETES OBESITY AND METABOLISM, 10 (4). pp. 336-342. [Journal article]

McClean, Paula, Irwin, Nigel, Hunter, Kerry, Gault, Victor and Flatt, Peter (2008) (Pro(3)) GIP[mPEG]: novel, long-acting, mPEGylated antagonist of gastric inhibitory polypeptide for obesity-diabetes (diabesity) therapy. BRITISH JOURNAL OF PHARMACOLOGY, 155 (5). pp. 690-701. [Journal article]

Taylor, Ashley, Irwin, Nigel, McKillop, Aine, Flatt, Peter and Gault, Victor (2008) Sub-chronic administration of the 11 beta-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity. BIOLOGICAL CHEMISTRY, 389 (4). pp. 441-445. [Journal article]

2007

Duffy, Nicola A, Green, Brian D, Irwin, Nigel, Gault, Victor, McKillop, Aine, O'Harte, Finbarr and Flatt, Peter (2007) Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: Nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1. EUROPEAN JOURNAL OF PHARMACOLOGY, 568 (1-3). pp. 278-286. [Journal article]

Gault, Victor, Hunter, Kerry, Irwin, Nigel, Green, Brian D, Greer, Brett, Harriott, Patrick, O'Harte, Finbarr and Flatt, Peter (2007) Characterisation and biological activity of Glu(3) amino acid substituted GIP receptor antagonists. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 461 (2). pp. 263-274. [Journal article]

Gault, Victor, Hunter, Kerry, Irwin, Nigel, Greer, Brett, Green, Brian D, Harriott, Patrick, O'Harte, Finbarr and Flatt, Peter (2007) Characterisation and glucoregulatory actions of a novel acylated form of the (Pro(3))GIP receptor antagonist in type 2 diabetes. BIOLOGICAL CHEMISTRY, 388 (2). pp. 173-179. [Journal article]

Gault, Victor, McClean, Paula, Cassidy, R. S., Irwin, Nigel and Flatt, Peter (2007) Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets. DIABETOLOGIA, 50 (8). pp. 1752-1762. [Journal article]

Gault, Victor, McClean, Paula, Irwin, Nigel, McCluskey, Janie and Flatt, Peter (2007) Effects of GIP-receptor antagonism in a streptozotocin-induced model of insulin deficiency. DIABETIC MEDICINE, 24 (Suppl. 1). p. 40. [Journal article]

Gault, Victor, McClean, Paula, Irwin, Nigel, Power, Gavin J., McCluskey, Janie and Flatt, Peter (2007) Effects of subchronic treatment with the long-acting glucose-dependent insulinotropic polypeptide receptor agonist, N-AcGIP, on glucose homeostasis in Streptozotocin-induced diabetes. PANCREAS, 35 (1). pp. 73-79. [Journal article]

Gault, Victor, Taylor, AI, Irwin, Nigel, McKillop, Aine and Flatt, Peter (2007) Effects of 11 beta-hydroxysteroid dehydrogenase inhibition on body weight and glucose homeostasis in mice with diet-induced obesity. DIABETOLOGIA, 50 (Suppl. 1). 0659. [Journal article]

Gault, Victor, Taylor, AI, Irwin, Nigel, McKillop, Aine and Flatt, Peter (2007) Metabolic effects of 11beta-hydroxysteroid dehydrogenase inhibition in an animal model of diet-induced obesity. Irish Journal of Medical Science , 176 (S9) . p. 382. [Journal article]

Gengler, Simon, Gault, Victor, Harriott, Patrick and Holscher, Christian (2007) Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid (25-35) are dependent on stimulation-protocol and genetic background. EXPERIMENTAL BRAIN RESEARCH, 179 (4). pp. 621-630. [Journal article]

Gengler, Simon, Gault, Victor, Harriott, Peter and Holscher, Christian (2007) Beta-amyloid (25-35) induced impairments of hippocampal synaptic plasticity are dependent on stimulation-protocol, genetic background, and aggregation state. Exp Brain Res, 179 . pp. 621-632. [Journal article]

Holscher, Christian, Gengler, S, Gault, Victor, Harriott, P and Mallot, HA (2007) Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning. European Journal of Pharmacology , 561 . pp. 85-90. [Journal article]

Irwin, Nigel, McClean, Paula, Cassidy, Roslyn S, O'Harte, Finbarr, Green, Brian D, Gault, Victor, Harriott, Patrick and Flatt, Peter (2007) Comparison of the anti-diabetic effects of GIP- and GLP-1-receptor activation in obese diabetic (ob/ob) mice: studies with DPP IV resistant N-AcGIP and exendin(1-39)amide. DIABETES-METABOLISM RESEARCH AND REVIEWS, 23 (7). pp. 572-579. [Journal article]

Irwin, Nigel, McClean, Paula, O'Harte, Finbarr, Gault, Victor, Harriott, P and Flatt, Peter (2007) Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. DIABETOLOGIA, 50 (7). pp. 1532-1540. [Journal article]

Irwin, Nigel, Parker, JC, Gault, Victor, Greer, B, Harriott, P, O'Harte, Finbarr and Flatt, Peter (2007) N-terminally truncated metabolite of glucose-dependent insulinotropic polypeptide (GIP) but not glucagon-like peptide-1 (GLP-1) improves glucose homeostasis in ob/ob mice through alleviation of insulin resistance. DIABETIC MEDICINE, 24 (Suppl. 1). p. 22. [Journal article]

McClean, Paula, Gault, Victor, Irwin, Nigel, Power, G. J., McCluskey, Janie and Flatt, Peter (2007) Effects of daily administration of the glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, N-Acetyl-GIP, in streptozotocin-incluced diabetic mice. DIABETIC MEDICINE, 24 (Suppl. 1). pp. 40-41. [Journal article]

McClean, Paula, Irwin, Nigel, Cassidy, Roslyn S., Holst, Jens J., Gault, Victor and Flatt, Peter (2007) GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 293 (6). E1746-E1755. [Journal article]

McKillop, Aine, Duffy, NA, Green, BD, Irwin, Nigel, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2007) Antidiabetic action of nateglinide includes augmentation of glucagon-like peptide-1 activity mediated partly through inhibition of DPP IV mediated degradation. DIABETOLOGIA, 50 (Suppl. 1). 0882. [Journal article]

O'Harte, Finbarr, Hunter, Kerry, Gault, Victor, Irwin, Nigel, Green, Brian D., Greer, Brett, Harriott, Patrick, Bailey, Clifford J. and Flatt, Peter (2007) Antagonistic effects of two novel GIP analogs, (Hyp(3))GIP and (Hyp(3)) GIPLys(16)PAL, on the biological actions of GIP and longer-term effects in diabetic ob/ob mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 292 (6). E1674-E1682. [Journal article]

O'Harte, Finbarr, Irwin, Nigel, Gault, Victor, McClean, Paula, Cassidy, RS, Harriott, P and Flatt, Peter (2007) Antidiabetic effects of sub-chronic administration of stable incretin mimetics N-AcGIP and exendin-4 (1-39) amide in obese-diabetic mice. DIABETIC MEDICINE, 24 (Suppl. 1). p. 22. [Journal article]

Parker, Jeremy C, Irwin, Nigel, Lavery, Kerry S, Green, Brian D, O'Harte, Finbarr, Gault, Victor and Flatt, Peter (2007) Metabolic effects of sub-chronic ablation of the incretin receptors by daily administration of (Pro(3))GIP and exendin(9-39)amide in obese diabetic (ob/ob) mice. BIOLOGICAL CHEMISTRY, 388 (2). pp. 221-226. [Journal article]

2006

Alana, I, Parker, JC, Gault, Victor, Flatt, Peter, O'Harte, Finbarr, Malthouse, JPG and Hewage, CM (2006) NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water. JOURNAL OF BIOLOGICAL CHEMISTRY, 281 (24). pp. 16370-16376. [Journal article]

Alana, I, Parker, JC, Gault, Victor, O'Harte, Finbarr, Malthouse, JP and Hewage, C (2006) NMR and modelling studies of glucose-dependent insulinotropic polypeptide (GIP). Journal of Peptide Science, 12 . p. 185. [Journal article]

Flatt, Peter, Irwin, Nigel, McClean, Paula, Green, BD, Gault, Victor, Bailey, CJ and O'Harte, Finbarr (2006) Early administration of the GIP receptor antagonist (Pro(3))GIP counters development of hyperglycaemia, glucose intolerance and insulin resistance in genetic obesity. DIABETOLOGIA, 49 (Suppl. 1). 0171. [Journal article]

Gault, Victor, Hunter, Kerry, Irwin, Nigel, Green, BD, O'Harte, Finbarr and Flatt, Peter (2006) Characterisation of novel glucose-dependent insulinotropic polypeptide (GIP) antagonists generated through amino acid substitution at position Glu(3). DIABETOLOGIA, 49 (Suppl. 1). 0672. [Journal article]

Gault, Victor, Irwin, Nigel, Green, BD, O'Harte, Finbarr and Flatt, Peter (2006) Long-acting glucose-dependent insulinotropic polypeptide (GIP) receptor agonist restores beta-cell glucose responsiveness in ageing mice. Diabetic Medicine , 23 (S2) . p. 31. [Journal article]

Green, Brian D, Irwin, Nigel, Duffy, Nicola A, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2006) Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1. EUROPEAN JOURNAL OF PHARMACOLOGY, 547 (1-3). pp. 192-199. [Journal article]

Green, Brian D., Irwin, Nigel, Cassidy, Roslyn S., Gault, Victor and Flatt, Peter (2006) Long-term administration of PACAP receptor antagonist, PACAP(6-27), impairs glucose tolerance and insulin sensitivity in obese diabetic ob/ob mice. PEPTIDES, 27 (9). pp. 2343-2349. [Journal article]

Irwin, Nigel, Clarke, GC, Gault, Victor, Green, BD, Harriott, P, O'Harte, Finbarr and Flatt, Peter (2006) Long-acting analogues of GIP with significantly improved antihyperglycaemic and insulinotropic properties: N-terminal modification versus mid-chain acylation. DIABETOLOGIA, 49 (Suppl. 1). 0172. [Journal article]

Irwin, Nigel, Clarke, Gillian C, Green, Brian D, Greer, Brett, Harriott, Patrick, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2006) Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide. BIOCHEMICAL PHARMACOLOGY, 72 (6). pp. 719-728. [Journal article]

Irwin, Nigel, Gault, Victor, Green, BD, Greer, B, Harriott, P, Bailey, CJ, O'Harte, Finbarr and Flatt, Peter (2006) Novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide (GIP) with enhanced antihyperglycaemic and insulinotropic properties. Diabetic Medicine, 23 (S2) . p. 8. [Journal article]

Irwin, Nigel, Green, BD, Gault, Victor, Cassidy, RS, O'Harte, Finbarr, Harriott, P and Flatt, Peter (2006) Effects on glucose homeostasis and insulin secretion of long term activation of the glucose-dependent insulinotropic polypeptide (GIP) receptor by N-AcGIP(LysPAL(37)) in normal mice. PEPTIDES, 27 (4). pp. 893-900. [Journal article]

Irwin, Nigel, Green, BD, Gault, Victor, Harriot, P, O'Harte, Finbarr and Flatt, Peter (2006) Stable agonist of glucose-dependent insulinotropic polypeptide (GIP) restores pancreatic beta cell glucose responsiveness but not glucose intolerance in aging mice. EXPERIMENTAL GERONTOLOGY, 41 (2). pp. 151-156. [Journal article]

Irwin, Nigel, Green, Brian D, Parker, Jeremy C, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2006) Biological activity and antidiabetic potential of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide, GIP(1-16) and (Pro(3))GIP(1-16). REGULATORY PEPTIDES, 135 (1-2). pp. 45-53. [Journal article]

Irwin, Nigel, O'Harte, Finbarr, Gault, Victor, Green, BD, Greer, B, Harriott, P, Bailey, CJ and Flatt, Peter (2006) GIP(Lys(16)PAL) and GIP(LyS(37)PAL): Novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential. JOURNAL OF MEDICINAL CHEMISTRY, 49 (3). pp. 1047-1054. [Journal article]

O'Harte, Finbarr, Hunter, K., Gault, Victor, Irwin, Nigel, Harriott, P. and Flatt, Peter (2006) Cellular and metabolic evaluation of (hydroxyproline(3))-GIP as new stable GIP receptor antagonist with antidiabetic potential. DIABETOLOGIA, 49 (Suppl. 1). 0661. [Journal article]

O'Harte, Finbarr, Irwin, Nigel, Green, BD, Gault, Victor, Cassidy, RS, Harriott, P and Flatt, Peter (2006) Administration of fatty acid linked glucose-dependent insulinotropic polypeptide receptor antagonist for two weeks improves glucose tolerance in normal mice. Diabetic Medicine , 23 (S2) . p. 22. [Journal article]

Parker, JC, Lavery, KS, Irwin, Nigel, Green, BD, Greer, B, Harriott, P, O'Harte, Finbarr, Gault, Victor and Flatt, Peter (2006) Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1 (9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice. JOURNAL OF ENDOCRINOLOGY, 191 (1). pp. 93-100. [Journal article]

2005

Gault, Victor, Irwin, Nigel, Green, BD, McCluskey, Janie, Greer, B, Bailey, CJ, Harriott, P, O'Harte, Finbarr and Flatt, Peter (2005) Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro(3))GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes. DIABETES, 54 (8). pp. 2436-2446. [Journal article]

Green, BD, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2005) A comparison of the cellular and biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. DIABETES OBESITY AND METABOLISM, 7 (5). pp. 595-604. [Journal article]

Green, BD, Irwin, Nigel, Gault, Victor, Bailey, CJ, O'Harte, Finbarr and Flatt, Peter (2005) Chronic treatment with exendin(9-39)amide indicates a minor role for endogenous glucagon-like peptide-1 in metabolic abnormalities of obesity-related diabetes in ob/ob mice. JOURNAL OF ENDOCRINOLOGY, 185 (2). pp. 307-317. [Journal article]

Green, Brian, Irwin, Nigel, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2005) Development and therapeutic potential of incretin hormone analogues for type 2 diabetes. The British Journal of Diabetes and Vascular Disease , 5 . pp. 134-140. [Journal article]

Irwin, Nigel, Gault, Victor, Green, BD, Greer, B, Harriott, P, Bailey, CJ, O'Harte, Finbarr and Flatt, Peter (2005) Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL(16)) and N-AcGIP(LysPAL(37)). BIOLOGICAL CHEMISTRY, 386 (7). pp. 679-687. [Journal article]

Irwin, Nigel, Green, BD, Gault, Victor, Greer, B, Harriott, P, Bailey, CJ, Flatt, Peter and O'Harte, Finbarr (2005) Degradation, insulin secretion, and antihyperglycemic actions of two palmitate-derivitized N-terminal pyroglutamyl analogues of glucose-dependent insulinotropic polypeptide. JOURNAL OF MEDICINAL CHEMISTRY, 48 (4). pp. 1244-1250. [Journal article]

Irwin, Nigel, Green, BD, Mooney, MH, Greer, B, Harriott, P, Bailey, CJ, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2005) A novel, long-acting agonist of glucose-dependent insulinotropic polypeptide suitable for once-daily administration in type 2 diabetes. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 314 (3). pp. 1187-1194. [Journal article]

Lavery, KS, Green, BD, Parker, JC, Irwin, Nigel, Gault, Victor, Flatt, Peter and O'Harte, Finbarr (2005) The truncated peptide glucagon-like peptide-1(9-36)amide has no insulin releasing activity but retains a significant effect on glucose disposal in vitro and in vivo. Diabetic Medicine, 22 (S2) . p. 17. [Journal article]

O'Harte, Finbarr, Irwin, Nigel, Green, BD, Harriott, P, Greer, B, Gault, Victor and Flatt, Peter (2005) Once daily administration of (Pro3)GIP ameliorates glucose intolerance and improves insulin sensitivity in obese diabetic (ob/ob) mice. Irish Journal of Medical , 174 (S2) . p. 8. [Journal article]

2004

Alana, I, Hewage, CM, Malthouse, JP, Parker, JC, Gault, Victor and O'Harte, Finbarr (2004) NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide. Biochemical and Biophysical Research Communications , 325 . pp. 281-286. [Journal article]

Flatt, Peter, Irwin, Nigel, Green, BD, Harriott, P, Gault, Victor and O'Harte, Finbarr (2004) Daily administration of GIP receptor antagonist alleviates glucose intolerance and counters insulin resistance in an animal model of obesity and type 2 diabetes. Diabetologia, 47 (S1) . p. 282. [Journal article]

Gault, Victor, Green, BD, Irwin, Nigel, Harriott, P, Greer, B, Flatt, Peter and O'Harte, Finbarr (2004) Development and characterisation of novel N-terminal Glu9-substituted agonists of glucagon-like peptide-1 (GLP-1). Diabetic Medicine, 21 (S2) . p. 26. [Journal article]

Gault, Victor, Irwin, Nigel, O'Harte, Finbarr, Green, BD and Flatt, Peter (2004) Antidiabetic potential of a long-acting derivative of GIP following once daily administration in type 2 diabetes. REGULATORY PEPTIDES, 122 (1). A55. [Journal article]

Green, BD, Gault, Victor, Flatt, Peter, Harriott, P, Greer, B and O'Harte, Finbarr (2004) Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala(8)/Ala(2) with 2-aminobutyric acid. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 428 (2). pp. 136-143. [Journal article]

Green, BD, Gault, Victor, Mooney, MH, Irwin, Nigel, Harriott, P, Greer, B, Bailey, CJ, O'Harte, Finbarr and Flatt, Peter (2004) Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala(8)-substituted GLP-1 analogues. BIOLOGICAL CHEMISTRY, 385 (2). pp. 169-177. [Journal article]

Green, BD, Gault, Victor, Mooney, MH, Irwin, Nigel, Harriott, P, Greer, B, O'Harte, Finbarr and Flatt, Peter (2004) Molecular, cellular and biological characteristics of DPP IV-resistant acetylated analogues of GLP-1. Diabetic Medicine, 21 (S2) . p. 26. [Journal article]

Green, BD, Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2004) Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypcptide (GIP) as future antidiabetic agents. CURRENT PHARMACEUTICAL DESIGN, 10 (29). pp. 3651-3662. [Journal article]

Green, BD, Irwin, Nigel, Gault, Victor, O'Harte, Finbarr, Bailey, CJ and Flatt, Peter (2004) Chronic treatment of obese hyperglycaemic ob/ob mice with exendin(9-39)amide suggests a minor role for endogenous GLP-1 in metabolic abnormalities of obesity-diabetes. DIABETOLOGIA, 47 (Suppl. 1). p. 659. [Journal article]

Green, BD, Mooney, MH, Gault, Victor, Irwin, Nigel, Bailey, CJ, Harriott, P, Greer, B, Flatt, Peter and O'Harte, Finbarr (2004) Lys(9) for Glu(9) substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39). METABOLISM-CLINICAL AND EXPERIMENTAL, 53 (2). pp. 252-259. [Journal article]

Green, BD, Mooney, MH, Gault, Victor, Irwin, Nigel, Bailey, CJ, Harriott, P, Greer, B, O'Harte, Finbarr and Flatt, Peter (2004) N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity. JOURNAL OF ENDOCRINOLOGY, 180 (3). pp. 379-388. [Journal article]

Hunter, Kerry, Irwin, Nigel, Green, BD, Flatt, Peter, O'Harte, Finbarr and Gault, Victor (2004) Novel long-acting enzyme-resistant glucose-dependent insulinotropic polypeptide receptor agonists with improved antihyperglycaemic and insulinotropic activity. Irish Journal of Medical Science, 173 (S1) . p. 35. [Journal article]

Irwin, Nigel, Gault, Victor, Green, BD, Greer, B, McCluskey, Janie, Harriott, P, O'Harte, Finbarr and Flatt, Peter (2004) Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice. BIOLOGICAL CHEMISTRY, 385 (9). pp. 845-852. [Journal article]

Irwin, Nigel, Gault, Victor, Green, BD, Harriott, P, O'Harte, Finbarr and Flatt, Peter (2004) Long-acting Tyr(1)-modified analogues of GIP with significantly improved antihyperglycaemic and insulinotropic properties. DIABETOLOGIA, 47 (Suppl. 1). p. 109. [Journal article]

Liu, HK, Green, BD, Gault, Victor, McCluskey, Janie, McClenaghan, Neville, O'Harte, Finbarr and Flatt, Peter (2004) N-acetyl-GLP-1: a DPP IV-resistant analogue of glucagon-like peptide-1 (GLP-1) with improved effects on pancreatic beta-cell-associated gene expression. CELL BIOLOGY INTERNATIONAL, 28 (1). pp. 69-73. [Journal article]

McCluskey, Janie, Irwin, Nigel, Gault, Victor, Green, BD, Flatt, Peter and O'Harte, Finbarr (2004) Longer-term ablation of GIP signalling in normal mice demonstrates importance of GIP for glucose homeostasis as part of the enteroinsular axis. Proceedings of the EASD Islet Study Group, Meeting on Molecular Aspects of Pancreatic Islet Function, 1 . p. 26. [Journal article]

O'Harte, Finbarr, Green, BD, Gault, Victor, Irwin, Nigel, Mooney, MH, Harriott, P, Greer, B and Flatt, Peter (2004) (Lys9)GLP-1 lacks insulinotropic activity but acts as a potent novel GLP-1 receptor antagonist in vivo. Diabetic Medicine, 21 (S2) . p. 43. [Journal article]

O'Harte, Finbarr, Irwin, Nigel, Gault, Victor, Green, BD and Flatt, Peter (2004) Assessment of the antidiabetic potential of two fatty acid derivatized GIP analogues. REGULATORY PEPTIDES, 122 (1). A105. [Journal article]

O'Harte, Finbarr, Irwin, Nigel, Gault, Victor, Green, BD and Flatt, Peter (2004) C-16 fatty acid derivatised GIP analogues as potential agents for diabetes therapy. Irish Journal of Medical Science, 173 (S1) . p. 10. [Journal article]

2003

Gault, Victor, Flatt, Peter, Harriott, P, Mooney, MH, Bailey, CJ and O'Harte, Finbarr (2003) Improved biological activity of Gly(2)- and Ser(2)-substituted analogues of glucose-dependent insulinotrophic polypeptide. JOURNAL OF ENDOCRINOLOGY, 176 (1). pp. 133-141. [Journal article]

Gault, Victor, Flatt, Peter and O'Harte, Finbarr (2003) Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 308 (2). pp. 207-213. [Journal article]

Gault, Victor, Irwin, Nigel, Harriott, P, Flatt, Peter and O'Harte, Finbarr (2003) DPP IV resistance and insulin releasing activity of a novel di-substituted analogue of glucose-dependent insulinotropic polypeptide, (Ser(2)-Asp(13))GIP. CELL BIOLOGY INTERNATIONAL, 27 (1). pp. 41-46. [Journal article]

Gault, Victor, O'Harte, Finbarr and Flatt, Peter (2003) Glucose-dependent insulinotropic polypeptide (GIP): anti-diabetic and anti-obesity potential? NEUROPEPTIDES, 37 (5). pp. 253-263. [Journal article]

Gault, Victor, O'Harte, Finbarr, Harriott, P and Flatt, Peter (2003) Degradation, cyclic adenosine monophosphate production, insulin secretion, and glycemic effects of two novel N-terminal Ala(2)-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo. METABOLISM-CLINICAL AND EXPERIMENTAL, 52 (6). pp. 679-687. [Journal article]

Gault, Victor, O'Harte, Finbarr, Harriott, P, Mooney, MH, Green, BD and Flatt, Peter (2003) Effects of the novel (Pro(3))GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin. DIABETOLOGIA, 46 (2). pp. 222-230. [Journal article]

Gault, Victor, Parker, JC, Harriott, P, Mooney, MH, Flatt, Peter and O'Harte, Finbarr (2003) Major metabolite of glucose-dependent insulinotropic polypeptide (GIP), GIP(3-42), acts as a GIP receptor antagonist in vivo. Diabetic Medicine, 20 (S2) . p. 36. [Journal article]

Green, BD, Gault, Victor, Harriott, P, Greer, B, Mooney, MH, Flatt, Peter and O'Harte, Finbarr (2003) Stability, cAMP production, insulin secretion and antihyperglycaemic activity of Pro3-substituted analogues of GLP-1 and GIP. Diabetic Medicine, 20 (S2) . p. 36. [Journal article]

Green, BD, Gault, Victor, Irwin, Nigel, Mooney, MH, Bailey, CJ, Harriott, P, Greer, B, Flatt, Peter and O'Harte, Finbarr (2003) Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu(9)-substituted analogues of glucagon-like peptide-1. BIOLOGICAL CHEMISTRY, 384 (12). pp. 1543-1551. [Journal article]

Green, BD, Gault, Victor, Monney, MH, Irwin, Nigel, Harriott, P, Greer, B, O'Harte, Finbarr and Flatt, Peter (2003) Dipeptidylpeptidase IV degradation, receptor binding, insulin-secreting and antihyperglycaemic characteristics of palmitate-derivitised glucagon-like peptide-1(7-36)amide analogues. Irish Journal of Medical Science, 172 (S1) . p. 41. [Journal article]

Green, BD, Gault, Victor, Mooney, MH, Irwin, Nigel, Bailey, CJ, Harriott, P, Greer, B, Flatt, Peter and O'Harte, Finbarr (2003) Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo. JOURNAL OF MOLECULAR ENDOCRINOLOGY, 31 (3). pp. 529-540. [Journal article]

Irwin, Nigel, Gault, Victor, Flatt, Peter, Mooney, MH and O'Harte, Finbarr (2003) Biological activity of mono- and di-substituted analogues of gastric inhibitory polypeptide (GIP). Proceedings of BioNet Annual Conference, 1 . p. 28. [Journal article]

Irwin, Nigel, Green, BD, Lui, HK, McCluskey, Janie, McClenaghan, Neville, Gault, Victor, Harriott, P, Greer, B, O'Harte, Finbarr and Flatt, Peter (2003) Dipeptidylpeptidase IV-resistant glucagon-like peptide-1(7-36)amide analogue N-acetyl-GLP-1 has improved effects on pancreatic beta-cell associated gene expression. Irish Journal of Medical Science, 172 (S1) . p. 24. [Journal article]

Mooney, MH, Gault, Victor, Harriott, P, Flatt, Peter and O'Harte, Finbarr (2003) Fragment peptides reveal bioactive domains critical for insulin-releasing activity of glucose-dependent insulinotropic polypeptide. Diabetic Medicine, 20 (S2) . p. 35. [Journal article]

O'Harte, Finbarr, Gault, Victor, Harriott, P, Irwin, Nigel, Mooney, MH and Flatt, Peter (2003) Biological activity of two novel N-terminal Ala2-substituted analogues of glucose-dependent insulinotropic polypeptide. Diabetic Medicine, 20 (S2) . p. 35. [Journal article]

O'Harte, Finbarr, Green, BD, Mooney, MH, Gault, Victor, Irwin, Nigel, Harriott, P, Greer, B and Flatt, Peter (2003) Comparison of the activity of the novel dipeptidylpeptidase IV-resistant GLP-1 receptor antagonist (Lys9)GLP-1 with GLP-1(9-36)amide and exendin-4(9-39). Irish Journal of Medical Science, 172 (S1) . p. 10. [Journal article]

2002

Flatt, Peter, Gault, Victor, Harriott, P, Greer, B, Mooney, MH, Bailey, CJ and O'Harte, Finbarr (2002) Novel N-Fmoc and N-palmitate analogues of glucose-dependent insullinotropic polypeptide exhibit DPP IV resistance, increased insulin-releasing activity and antidiabetic action. DIABETOLOGIA, 45 (Suppl. 2). p. 546. [Journal article]

Gault, Victor, Flatt, Peter, Bailey, CJ, Harriott, P, Greer, B, Mooney, MH and O'Harte, Finbarr (2002) Enhanced cAMP generation and insulin-releasing potency of two novel Tyr(1)-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes. BIOCHEMICAL JOURNAL, 367 (Part 3). pp. 913-920. [Journal article]

Gault, Victor, Green, BD, Greer, B, Harriott, P, Flatt, Peter and O'Harte, Finbarr (2002) N-terminally modified analogues of glucose-dependent insulinotropic polypeptide exhibit improved insulinotropic activity and antihyperglycaemic potential compared with glucagon-like peptide-1 counterparts. DIABETOLOGIA, 45 (Suppl. 2). p. 545. [Journal article]

Gault, Victor, Harriott, P, Flatt, Peter and O'Harte, Finbarr (2002) Cyclic AMP production and insulin releasing activity of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide. BIOSCIENCE REPORTS, 22 (5-6). pp. 523-528. [Journal article]

Gault, Victor, O'Harte, Finbarr, Harriott, P and Flatt, Peter (2002) Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 290 (5). pp. 1420-1426. [Journal article]

Gault, Victor, Parker, JC, Harriott, P, Flatt, Peter and O'Harte, Finbarr (2002) Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo. JOURNAL OF ENDOCRINOLOGY, 175 (2). pp. 525-533. [Journal article]

Mooney, MH, Gault, Victor, Flatt, Peter, Harriott, P, Greer, B, Bailey, CJ and O'Harte, Finbarr (2002) Antidiabetic potential of four novel analogues of glucose-dependent insulinotropic polypeptide demonstrated in an animal model of Type 2 diabetes. DIABETOLOGIA, 45 (Suppl. 2). p. 547. [Journal article]

Mooney, MH, Gault, Victor, Flatt, Peter, Harriott, P and O'Harte, Finbarr (2002) N-terminally modified degradation resistant analogues of glucose-dependent insulinotropic polypeptide display enhanced antidiabetic action. Irish Journal of Medical Science, 171 (S3) . p. 9. [Journal article]

O'Harte, Finbarr, Gault, Victor, Harriott, H, Green, BD and Flatt, Peter (2002) Receptor antagonist studies indicate that GIP is a more important enteroinsular axis hormone than GLP-1 in obese diabetic (ob/ob) mice. Irish Journal of Medical Science, 171 (S3) . p. 18. [Journal article]

O'Harte, Finbarr, Gault, Victor, Harriott, P, Green, BD and Flatt, Peter (2002) Comparative studies with exendin(9-39)amide and the novel (Pro(3))GIP receptor antagonist indicates that glucose-dependent insulinotropic polypeptide is the major hormone of the enteroinsular axis. DIABETOLOGIA, 45 (Suppl. 2). p. 548. [Journal article]

O'Harte, Finbarr, Gault, Victor, Parker, JC, Harriott, P, Mooney, MH, Bailey, CJ and Flatt, Peter (2002) Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP. DIABETOLOGIA, 45 (9). pp. 1281-1291. [Journal article]

2001

Flatt, Peter, Gault, Victor, Harriott, P and O'Harte, Finbarr (2001) Antagonist actions of novel (Pro(3))GIP analogue and GIP(3-42) on cyclic AMP production and insulin secretion. DIABETOLOGIA, 44 (Suppl. 1). p. 748. [Journal article]

Gault, Victor, Harriott, P, Flatt, Peter and O'Harte, Finbarr (2001) GIP analogues substituted at Ala(2) exhibit improved plasma stability and insulin-releasing activity. DIABETOLOGIA, 44 (Suppl. 1). p. 747. [Journal article]

Mooney, MH, Flatt, Peter, Gault, Victor and O'Harte, Finbarr (2001) Detection of glycated glucose dependent insulinotropic polypeptide in the intestines of diabetic mice and assessment of its biological activity in vitro. Irish Journal of Medical Science, 170 (S2) . p. 11. [Journal article]

Mooney, MH, Gault, Victor, Abdel-Wahab, Yasser, Flatt, Peter and O'Harte, Finbarr (2001) Identification of Tyr(1)-glucitol GIP in intestines of diabetic mice with enhanced insulin-releasing activity. DIABETOLOGIA, 44 (Suppl. 1). p. 1223. [Journal article]

O'Harte, Finbarr, Gault, Victor, Harriott, P, Parker, JC and Flatt, Peter (2001) DPP IV resistant N-terminally modified GIP analogues with enhanced insulinotropic activity. DIABETOLOGIA, 44 (Suppl. 1). p. 746. [Journal article]

O'Harte, Finbarr, Gault, Victor, Harriott, P, Parker, JC and Flatt, Peter (2001) Stable amino terminally-modified analogues of glucose-dependent insulinotropic polypeptide with improved insulin-releasing activity. Irish Journal of Medical Science, 170 (S2) . p. 10. [Journal article]

1999

Gault, Victor, Harriott, P, Flatt, Peter and O'Harte, Finbarr (1999) Stability of GIP and amino terminally modified GIP analogues to DPP IV and human plasma. Digestion, 60 . p. 504. [Journal article]

This list was generated on Sat Dec 20 08:07:18 2014 GMT.