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Number of items: 56.

2013

Bowman, Karen J, Al-Moneef, Manar M, Sherwood, Benedict T, Colquhoun, Alexandra J, Goddard, Jonathan C, Griffiths, T R Leyshon, Payne, David, Singh, Sadmeet, Butterworth, Paul C, Khan, Masood A, Summerton, Duncan J, Steward, William P, McKelvey-Martin, Valerie J, McKeown, Stephanie, Kockelbergh, Roger C, Mellon, J Kilian, Symonds, R Paul and Jones, George D D (2013) Comet assay measures of DNA damage are predictive of bladder cancer cell treatment sensitivityin vitroand outcomein vivo. International Journal of Cancer, TBC . n/a. [Journal article]

Ming, L, Byrne, N, Camac, SN, Ward, C, Mitchell, Christopher, Waugh, D, McKeown, Stephanie and Worthington, Jenny (2013) Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours; informed scheduling of the bioreductive drug AQ4N improves treatment response. International Journal of Cancer, 132 . pp. 1323-1332. [Journal article]

2012

Browne, G, Nesbitt, H, Ming, L, Stein, GS, Lian, JB, McKeown, SR and Worthington, Jenny (2012) Bicalutamide-induced hypoxia potentiates RUNX2-mediated Bcl-2 expression resulting in apoptosis resistance. British Journal of Cancer, 107 . pp. 1714-1721. [Journal article]

McKenna, Declan J, Doherty, Bernadette, Downes, Stephen, McKeown, SR and McKelvey-Martin, Valerie J (2012) Use of the Comet-FISH Assay to Compare DNA Damage and Repair in p53 and hTERT Genes following Ionizing Radiation. PLoS ONE, 7 (11). e49364. [Journal article]

2011

Worthington, Jenny, McKeown, Stephanie and Banat, Ibrahim (2011) A study of anti-cancer effects of Funalia trogii in vitro and in vivo. Food and Chemical Toxicology, 49 (7). pp. 1477-1483. [Journal article]

2010

Devlin, Andrea, Thompson, Paul, Robson, Tracy and McKeown, SR (2010) Cytochrome P450 1B1 mRNA Untranslated Regions Interact to Inhibit Protein Translation. Molecular Carcinogenesis, 49 (2). pp. 190-199. [Journal article]

2009

Devlin, Andrea, Mcllroy, Marie, McKeen, Hayley D., Bonde, Pramode, Menezes, A. A. Carlos, Swarbrick, Christine J., Robson, Tracy, Hirst, David G., Campbell, F. Charles, McGuigan, James A. and McKeown, Stephanie (2009) Cytochrome P450 1B1 Expression in Rat Esophageal Tumorigenesis Promoted by Gastric and Duodenal Reflux. MOLECULAR CARCINOGENESIS, 48 (2). pp. 110-117. [Journal article]

2008

Butterworth, Karl T, McCarthy, Helen O, Devlin, Andrea, Ming, Louise, Robson, Tracy, McKeown, Stephanie and Worthington, Jenny (2008) Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype. INTERNATIONAL JOURNAL OF CANCER, 123 (4). pp. 760-768. [Journal article]

McKenna, Declan J, McKeown, Stephanie and McKelvey-Martin, Valerie (2008) Potential use of the comet assay in the clinical management of cancer. MUTAGENESIS, 23 (3). pp. 183-190. [Journal article]

O'Keeffe, Martina B, Devlin, Andrea, Burns, Alan J, Gardiner, Tom A, Logan, Ian, Hirst, David G and McKeown, Stephanie (2008) Investigation of pericytes, hypoxia, and vascularity in bladder tumors: Association with clinical outcomes. ONCOLOGY RESEARCH, 17 (3). pp. 93-101. [Journal article]

O'Rourke, Martin, Ward, Claire, Worthington, Jenny, McKenna, Julie, Valentine, Andrea, Robson, Tracy, Hirst, David G and McKeown, Stephanie (2008) Evaluation of the antiangiogenic potential of AQ4N. CLINICAL CANCER RESEARCH, 14 (5). pp. 1502-1509. [Journal article]

Wilson, C, Scullin, P, Worthington, Jenny, Seaton, A, Maxwell, P, O'Rourke, D, Johnston, PG, McKeown, Stephanie, Wilson, RH, O'Sullivan, JM and Waugh, DJJ (2008) Dexamethasone potentiates the antiangiogenic activity of docetaxel in castration-resistant prostate cancer. BRITISH JOURNAL OF CANCER, 99 (12). pp. 2054-2064. [Journal article]

2007

McCarthy, HO, Worthington, Jenny, Barrett, E, Cosimo, E, Boyd, M, Mairs, RJ, Ward, C, McKeown, Stephanie, Hirst, DG and Robson, T (2007) p(21(WAF1))-mediated transcriptional targeting of inducible nitric oxide synthase gene therapy sensitizes tumours to fractionated radiotherapy. GENE THERAPY, 14 (3). pp. 246-255. [Journal article]

McKeown, Stephanie, Cowen, RL and Williams, KJ (2007) Bioreductive drugs: from concept to clinic. CLINICAL ONCOLOGY, 19 (6). pp. 427-442. [Journal article]

2006

Doherty, Sharon C, McKeown, SR, Lopez, Jesus A, Walsh, Ian K and McKelvey-Martin, Valerie J (2006) Gene expression in normal Urothelium depends on location within the bladder: A possible link to bladder carcinogenesis. European Urology, 50 (2). pp. 290-301. [Journal article]

Doherty, Sharon C, McKeown, Stephanie R, Lopez, Jesus A, Walsh, Ian K and McKelvey-Martin, Valerie (2006) Gene expression in normal Urothelium depends on location within the bladder: A possible link to bladder carcinogenesis. EUROPEAN UROLOGY, 50 (2). pp. 290-301. [Journal article]

McIlroy, M, O'Rourke, M, McKeown, Stephanie, Hirst, DG and Robson, T (2006) Pericytes influence endothelial cell growth characteristics: Role of plasminogen activator inhibitor type 1 (PAI-1). CARDIOVASCULAR RESEARCH, 69 (1). pp. 207-217. [Journal article]

McKeown, SR and Jones, B (2006) DNA repair: therapeutic implications. The British Journal of Radiology, 79 (938). pp. 91-93. [Journal article]

Yakkundi, A, McErlane, V, Murray, M, McCarthy, HO, Ward, C, Hughes, Ciara, Patterson, LH, Hirst, DG, McKeown, Stephanie and Robson, T (2006) Tumor-selective drug activation: a GDEPT approach utilizing cytochrome P450 1A1 and AQ4N. CANCER GENE THERAPY, 13 (6). pp. 598-605. [Journal article]

2005

McErlane, V, Yakkundi, A, McCarthy, HO, Hughes, Ciara, Patterson, LH, Hirst, DG, Robson, T and McKeown, Stephanie (2005) A cytochrome P4502B6 meditated gene therapy strategy to enhance the effects of radiation or cyclophosphamide when combined with the bioreductive drug AQ4N. JOURNAL OF GENE MEDICINE, 7 (7). pp. 851-859. [Journal article]

Robson, T, Worthington, Jenny, McKeown, Stephanie and Hirst, DG (2005) Radiogenic therapy: Novel approaches for enhancing tumor radiosensitivity. TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 4 (4). pp. 343-361. [Journal article]

2004

McCarthy, HO, Worthington, Jenny, Ward, C, Barrett, E, Hirst, DG, McKeown, Stephanie and Robson, T (2004) Use of the p2l/WAF1 promoter for transcriptional targetting in cancer gene therapy. JOURNAL OF GENE MEDICINE, 6 (9). p. 78. [Journal article]

McKeown, SR, Ward, C and Robson, T (2004) Gene-directed enzyme prodrug therapy: A current assessment. CURRENT OPINION IN MOLECULAR THERAPEUTICS, 6 (4). pp. 421-435. [Journal article]

2003

Doherty, SC, McKeown, Stephanie, McKelvey-Martin, Valerie, Downes, Stephen, Atala, A, Yoo, JJ, Simpson, DA and Kaufmann, WK (2003) Cell cycle checkpoint function in bladder cancer. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 95 (24). pp. 1859-1868. [Journal article]

Dunne, AL, Price, ME, Mothersill, C, McKeown, Stephanie, Robson, T and Hirst, DG (2003) Relationship between clonogenic radiosensitivity, radiation-induced apoptosis and DNA damage/repair in human colon cancer cells. BRITISH JOURNAL OF CANCER, 89 (12). pp. 2277-2283. [Journal article]

McCarthy, Helen, Yakkundi, A, McErlane, V, Hughes, Ciara, Keilty, G, Murray, Margaret, Patterson, LH, Hirst, DG, McKeown, SR and Robson, T (2003) Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N. Cancer Gene Therapy, 10 (1). pp. 40-48. [Journal article]

McKenna, Declan J, Rajah, NF, McKeown, Stephanie, McKerr, George and McKelvey-Martin, Valerie (2003) Use of the comet-FISH assay to demonstrate repair of the TP53 gene region in two human bladder carcinoma cell lines. RADIATION RESEARCH, 159 (1). pp. 49-56. [Journal article]

McKenna, DJ, Gallus, M, McKeown, Stephanie, Downes, Stephen and McKelvey-Martin, Valerie (2003) Modification of the alkaline Comet assay to allow simultaneous evaluation of mitomycin C-induced DNA cross-link damage and repair of specific DNA sequences in RT4 cells. DNA REPAIR, 2 (8). pp. 879-890. [Journal article]

McKeown, Stephanie, Robson, T, Price, ME, Ho, ETS, Hirst, DG and McKelvey-Martin, Valerie (2003) Potential use of the alkaline comet assay as a predictor of bladder tumour response to radiation. BRITISH JOURNAL OF CANCER, 89 (12). pp. 2264-2270. [Journal article]

2001

McGreal, Stanley, Hughes, Ciara, Murray, Margaret, Friery, OP, Patterson, LH, Hirst, DG and McKeown, SR (2001) The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N. British Journal of Cancer, 85 (4). pp. 625-629. [Journal article]

McKeown, Stephanie, Hughes, Ciara, Keilty, Gillian, McCarthy, Helen, Murray, Margaret, Hirst, David and Robson, Tracy (2001) Manipulation of P450 gene expression in tumours; A novel approach for targeted activation of bioreductive prodrugs. In: Invited presentations on cancer. Nature Publishing Group. Vol 85 (Suppl. 1) 1 pp. [Conference contribution]

2000

Al-Assar, O, Robson, T, McKeown, Stephanie, Gardin, I, Wilson, GD and Hirst, DG (2000) Regulation of FOS by different compartmental stresses induced by low levels of ionizing radiation. RADIATION RESEARCH, 154 (5). pp. 503-514. [Journal article]

Friery, OP, Gallagher, R, Murray, MM, Hughes, Ciara, Galligan, ES, McIntyre, Irene, Patterson, LH, Hirst, DG and McKeown, Stephanie (2000) Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine. BRITISH JOURNAL OF CANCER, 82 (8). pp. 1469-1473. [Journal article]

Martin, AR, Bailie, JR, Robson, T, McKeown, Stephanie, Al-Assar, O, McFarland, A and Hirst, DG (2000) Retinal pericytes control expression of nitric oxide synthase and endothelin-1 in microvascular endothelial cells. MICROVASCULAR RESEARCH, 59 (1). pp. 131-139. [Journal article]

Patterson, LH and McKeown, Stephanie (2000) AQ4N: a new approach to hypoxia-activated cancer chemotherapy. BRITISH JOURNAL OF CANCER, 83 (12). pp. 1589-1593. [Journal article]

Patterson, LH, McKeown, Stephanie, Ruparella, K, Double, JA, Bibby, MC, Cole, S and Stratford, IJ (2000) Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent. BRITISH JOURNAL OF CANCER, 82 (12). pp. 1984-1990. [Journal article]

Price, ME, McKelvey-Martin, Valerie, Robson, T, Hirst, DG and McKeown, Stephanie (2000) Induction and rejoining of DNA double-strand breaks in bladder tumor cells. RADIATION RESEARCH, 153 (6). pp. 788-794. [Journal article]

Robson, T, Price, ME, Moore, ML, Joiner, MC, McKelvey-Martin, Valerie, McKeown, Stephanie and Hirst, DG (2000) Increased repair and cell survival in cells treated with DIR1 antisense oligonucleotides: implications for induced radioresistance. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 76 (5). pp. 617-623. [Journal article]

Ruddock, MW, Burns, DM, McKeown, Stephanie, Murphy, L, WAlsh, IK, Keane, PF and Hirst, DG (2000) Contractile properties of human renal cell carcinoma recruited arteries and their response to nicotinamide. RADIOTHERAPY AND ONCOLOGY, 54 (2). pp. 179-184. [Journal article]

1999

Patterson, LH, McKeown, Stephanie, Robson, T, Gallagher, R, Raleigh, SM and Orr, S (1999) Antitumour prodrug development using cytochrome P450 (CYP) mediated activation. ANTI-CANCER DRUG DESIGN, 14 (6). pp. 473-486. [Journal article]

Robson, T, Joiner, MC, Wilson, GD, McCullough, William, Price, ME, Logan, Ian, Jones, H, McKeown, Stephanie and Hirst, DG (1999) A novel human stress response-related gene with a potential role in induced radioresistance. RADIATION RESEARCH, 152 (5). pp. 451-461. [Journal article]

1998

McKelvey-Martin, Valerie, Ho, ETS, McKeown, Stephanie, Johnston, SR, McCarthy, PJ, Rajab, NF and Downes, Stephen (1998) Emerging applications of the single cell gel electrophoresis (Comet) assay. I. Management of invasive transitional cell human bladder carcinoma. II. Fluorescent in situ hybridization Comets for the identification of damaged and repaired DNA sequences in individual cells. MUTAGENESIS, 13 (1). pp. 1-8. [Journal article]

Raleigh, SM, Wanogho, E, Burke, MD, McKeown, Stephanie and Patterson, LH (1998) Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 42 (4). pp. 763-767. [Journal article]

1996

Galligan, ES, Sweetman, SF, McKeown, SR and Strain, JJ (1996) An investigation of the radioprotective action of dietary antioxidants on P388 murine lymphoblastic cells. IRISH JOURNAL OF MEDICAL SCIENCE, 165 (4). pp. 304-305. [Journal article]

Hejmadi, MV, McKeown, SR, Friery, OP, McIntyre, Irene, Patterson, LH and Hirst, DG (1996) DNA damage following combination of radiation with the bioreductive drug AQ4N: Possible selective toxicity to oxic and hypoxic tumour cells. British Journal of Cancer , 73 (4). pp. 499-505. [Journal article]

1995

McKeown, SR, HEJMADI, MV, MCINTYRE, IA, MCALEER, JJA and PATTERSON, LH (1995) Aq4n - an alkylaminoanthraquinone n-oxide showing bioreductive potential and positive interaction with radiation in-vivo. British Journal of Cancer, 72 (1). pp. 76-81. [Journal article]

1993

JOINER, B, HIRST, VK, McKeown, SR, MCALEER, JJA and HIRST, DG (1993) The effect of recombinant-human-erythropoietin treatment on tumor radiosensitivity and cancer-associated anemia in the mouse. British Journal of Cancer, 68 (4). pp. 720-726. [Journal article]

1992

MCALEER, JJA, McKeown, SR, MACMANUS, MP, LAPPIN, TRJ and BRIDGES, JM (1992) Hypobaric hypoxia - a method for testing bioreductive drugs invivo. International Journal of Radiation Oncology Biology Physics, 23 (3). pp. 551-555. [Journal article]

1980

McKeown, SR and ALLEN, IV (1980) Brain temperature after death. Journal of Neuroscience Methods, 2 (1). pp. 103-105. [Journal article]

1979

ALLEN, IV, GLOVER, G, McKeown, SR and MCCORMICK, D (1979) Cellular-origin of lysosomal enzymes in the plaque in multiple-sclerosis .2. Histochemical-study with combined demonstration of myelin and acid-phosphatase. Neuropathology and Applied Neurobiology, 5 (3). pp. 197-210. [Journal article]

McKeown, SR (1979) Postmortem autolytic response in rat-brain lysosomes. Journal of Neurochemistry, 32 (2). pp. 391-396. [Journal article]

McKeown, SR and ALLEN, IV (1979) Fragility of cerebral lysosomes in multiple-sclerosis. Neuropathology and Applied Neurobiology, 5 (5). pp. 405-415. [Journal article]

1978

McKeown, SR (1978) Role of cerebral lysosomes in multiple-sclerosis. IRISH JOURNAL OF MEDICAL SCIENCE, 147 (3). p. 119. [Journal article]

McKeown, SR and ALLEN, IV (1978) Cellular origin of lysosomal enzymes in the plaque in multiple-sclerosis - combined histological and biochemical study. Neuropathology and Applied Neurobiology, 4 (6). pp. 471-482. [Journal article]

1977

McKeown, SR and ALLEN, IV (1977) Lysosomal involvement in pathogenesis of Multiple-Sclerosis. Biochemical Society Transactions, 5 (5). pp. 1416-1418. [Journal article]

1975

Williamson, DH, McKeown, SR and Ilic, V (1975) Metabolic Interactions of Glucose, Acetoacetate and Insulin in Mammary- Glad Slices of Lactating Rats. Biochemical Journal, 150 (2). pp. 145-152. [Journal article]

This list was generated on Tue Oct 21 08:36:41 2014 BST.