Conference contribution

O'Harte, FPM, McClean, PL and Irwin, N (2009) Structure function studies with glucagon related peptides reveal glucagon receptor antagonist activities in vitro and in vivo. In: 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna. UNSPECIFIED. 1 pp. [Conference contribution]

Journal article

McClean, Paula, Parthsarathy, Vadivel, Faivre, Emilie and Holscher, Christian (2011) The diabetes drug Liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. The Journal of Neuroscience, 31 (17). pp. 6587-6594. [Journal article]

Gengler, Simon, McClean, Paula, McCurtin, Ruth, Gault, Victor and Holscher, Christian (2010) Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol Aging, 000 . 000-000. [Journal article]

McClean, Paula, Gault, Victor A, Harriott, Patrick and Holscher, Christian (2010) Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease. EUROPEAN JOURNAL OF PHARMACOLOGY, 630 (1-3). pp. 158-162. [Journal article]

McClean, Paula, Parthsarathy, V., Faivre, E. and Holscher, Christian (2010) The novel GLP-1 analogue liraglutide has neuroprotective properties in a mouse model of Alzheimer's disease. REGULATORY PEPTIDES, 164 (1, Sp. Iss. SI). p. 40. [Journal article]

Holscher, Christian, Fung, K., McCurtin, R., Gault, Victor and McClean, Paula (2009) Novel GLP-1 analogues cross the blood brain barrier and enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease. DIABETOLOGIA, 52 (Suppl. 1). p. 790. [Journal article]

Irwin, Nigel, McClean, Paula, Hunter, Kerry and Flatt, Peter (2009) Metabolic effects of sustained activation of the GLP-1 receptor alone and in combination with background GIP receptor antagonism in high fat-fed mice. DIABETES OBESITY AND METABOLISM, 11 (6). pp. 603-610. [Journal article]

Irwin, Nigel, McClean, Paula, Patterson, Steven, Hunter, Kerry and Flatt, Peter (2009) Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes. BIOLOGICAL CHEMISTRY, 390 (1). pp. 75-80. [Journal article]

McClean, Paula, Gault, Victor, Harriott, Patrick and Holscher, Christian (2009) Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease. European journal of pharmacology, epub . [Journal article]

McClean, Paula, Gault, Victor, Irwin, Nigel, McCluskey, Janie and Flatt, Peter (2008) Daily administration of the GIP-R antagonist (Pro(3))GIP in streptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti-obesity-diabetes actions of (Pro(3))GIP. DIABETES OBESITY AND METABOLISM, 10 (4). pp. 336-342. [Journal article]

McClean, Paula, Irwin, Nigel, Hunter, Kerry, Gault, Victor and Flatt, Peter (2008) (Pro(3)) GIP[mPEG]: novel, long-acting, mPEGylated antagonist of gastric inhibitory polypeptide for obesity-diabetes (diabesity) therapy. BRITISH JOURNAL OF PHARMACOLOGY, 155 (5). pp. 690-701. [Journal article]

Gault, Victor, McClean, Paula, Cassidy, R. S., Irwin, Nigel and Flatt, Peter (2007) Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets. DIABETOLOGIA, 50 (8). pp. 1752-1762. [Journal article]

Gault, Victor, McClean, Paula, Irwin, Nigel, McCluskey, Janie and Flatt, Peter (2007) Effects of GIP-receptor antagonism in a streptozotocin-induced model of insulin deficiency. DIABETIC MEDICINE, 24 (Suppl. 1). p. 40. [Journal article]

Gault, Victor, McClean, Paula, Irwin, Nigel, Power, Gavin J., McCluskey, Janie and Flatt, Peter (2007) Effects of subchronic treatment with the long-acting glucose-dependent insulinotropic polypeptide receptor agonist, N-AcGIP, on glucose homeostasis in Streptozotocin-induced diabetes. PANCREAS, 35 (1). pp. 73-79. [Journal article]

Irwin, Nigel, McClean, Paula, Cassidy, Roslyn S, O'Harte, Finbarr, Green, Brian D, Gault, Victor, Harriott, Patrick and Flatt, Peter (2007) Comparison of the anti-diabetic effects of GIP- and GLP-1-receptor activation in obese diabetic (ob/ob) mice: studies with DPP IV resistant N-AcGIP and exendin(1-39)amide. DIABETES-METABOLISM RESEARCH AND REVIEWS, 23 (7). pp. 572-579. [Journal article]

Irwin, Nigel, McClean, Paula and Flatt, Peter (2007) Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic (ob/ob) mice. JOURNAL OF PEPTIDE SCIENCE, 13 (6). pp. 400-405. [Journal article]

Irwin, Nigel, McClean, Paula, Harriott, Patrick and Flatt, Peter (2007) Beneficial effects of sub-chronic activation of glucagon-like peptide-1 (GLP-1) receptors on deterioration of glucose homeostasis and insulin secretion in aging mice. EXPERIMENTAL GERONTOLOGY, 42 (4). pp. 296-300. [Journal article]

Irwin, Nigel, McClean, Paula, O'Harte, Finbarr, Gault, Victor, Harriott, P and Flatt, Peter (2007) Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. DIABETOLOGIA, 50 (7). pp. 1532-1540. [Journal article]

McClean, Paula, Gault, Victor, Irwin, Nigel, Power, G. J., McCluskey, Janie and Flatt, Peter (2007) Effects of daily administration of the glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, N-Acetyl-GIP, in streptozotocin-incluced diabetic mice. DIABETIC MEDICINE, 24 (Suppl. 1). pp. 40-41. [Journal article]

McClean, Paula, Irwin, Nigel, Cassidy, Roslyn S., Holst, Jens J., Gault, Victor and Flatt, Peter (2007) GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 293 (6). E1746-E1755. [Journal article]

O'Harte, Finbarr, Irwin, Nigel, Gault, Victor, McClean, Paula, Cassidy, RS, Harriott, P and Flatt, Peter (2007) Antidiabetic effects of sub-chronic administration of stable incretin mimetics N-AcGIP and exendin-4 (1-39) amide in obese-diabetic mice. DIABETIC MEDICINE, 24 (Suppl. 1). p. 22. [Journal article]

Flatt, Peter, Irwin, Nigel, McClean, Paula, Green, BD, Gault, Victor, Bailey, CJ and O'Harte, Finbarr (2006) Early administration of the GIP receptor antagonist (Pro(3))GIP counters development of hyperglycaemia, glucose intolerance and insulin resistance in genetic obesity. DIABETOLOGIA, 49 (Suppl. 1). 0171. [Journal article]