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THE GENOTYPE OF BONE-MARROW-DERIVED INFLAMMATORY CELLS DOES NOT ACCOUNT FOR DIFFERENCES IN SKELETAL-MUSCLE REGENERATION BETWEEN SJL/J AND BALB/C MICE

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Mitchell, Christopher, GROUNDS, MD and PAPADIMITRIOU, JM (1995) THE GENOTYPE OF BONE-MARROW-DERIVED INFLAMMATORY CELLS DOES NOT ACCOUNT FOR DIFFERENCES IN SKELETAL-MUSCLE REGENERATION BETWEEN SJL/J AND BALB/C MICE. CELL AND TISSUE RESEARCH, 280 (2). pp. 407-413. [Journal article]

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Abstract

This study determined whether the genotype of bone marrow-derived inflammatory cells contributes to the more pronounced leukocytic exudation and extensive new muscle formation seen in SJL/J compared with BALB/c mice after a crush-injury (Mitchell et al. 1992). Female SJL/J mice were whole-body irradiated and reconstituted with male bone marrow from the BALB/c strain, and irradiated BALB/c females reconstituted with male SJL/J bone marrow. The mice were allowed to recover for 3 weeks and the tibialis anterior muscle (in a leg which had been protected from irradiation) was injured by crushing. At 3 and 10 days after injury the extent of necrotic debris, mononuclear leukocytic infiltration and new muscle formation was assessed in the muscles. The SJL/J mice reconstituted with BALB/c bone marrow showed extensive mononuclear leukocytic infiltration and clearance of necrotic debris when compared with BALB/c mice reconstituted with SJL/J bone marrow, and these strain-specific differences mirrored those seen with control bone marrow reconstituted hosts and non-irradiated hosts. The results show that the genotype of the bone mac-row-derived macrophages is not responsible for the superior regeneration of crush-injured skeletal muscle in SJL/J mice, and it appears that factors intrinsic to the muscle tissue may be of central importance.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Molecular Medicine
Biomedical Sciences Research Institute > Molecular Medicine > Vascular Medicine
ID Code:9478
Deposited By:Dr Christopher Mitchell
Deposited On:23 Jan 2010 16:08
Last Modified:10 Jun 2010 11:02

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