Ulster University Logo

Ulster Institutional Repository

ASSOCIATION OF AN UNUSUAL FORM OF A PAX7-LIKE GENE WITH INCREASED EFFICIENCY OF SKELETAL-MUSCLE REGENERATION

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

KAY, PH, Mitchell, Christopher, AKKARI, A and PAPADIMITRIOU, JM (1995) ASSOCIATION OF AN UNUSUAL FORM OF A PAX7-LIKE GENE WITH INCREASED EFFICIENCY OF SKELETAL-MUSCLE REGENERATION. GENE, 163 (2). pp. 171-177. [Journal article]

Full text not available from this repository.

Abstract

Efficiency of regeneration of mechanically injured skeletal muscle is more pronounced in SJL/J mice, as compared to other laboratory strains in which regenerative properties of skeletal muscle are uniformly poor. Previously, we postulated that a small number of genes might differ between SJL/J and; other mouse strains, and would be responsible for this variation in the efficiency of skeletal muscle regeneration. The results of initial experiments demonstrated that SJL/J mice have a unique form of the myogenic gene, Myo-D1, which partly influences efficiency of skeletal muscle repair, and that other genes were also involved. To identify other candidate genes, differences were sought within the myogenic paired box/homeobox-containing gene Pax7 between SJL/J and other laboratory mouse strains. Southern blotting indicated that SJL/J, Quackenbush and DDO mice share a Pax7/TaqI RFLP which differs from all other laboratory strains tested. This RFLP is most likely due to sequence differences within the homeobox of a Pax7-like gene. In vivo studies revealed that Quackenbush and DDO mice also share the same regenerative properties of mechanically damaged skeletal muscle as SJL/J mice. Since Quackenbush and DDO mice lack the SJL/J type of Myo-D1, and DDO belong to a different mouse sub-species, these studies suggest that structural alterations in the homeobox of a Pax7-like gene may be implicated in the effectiveness of renewal of damaged skeletal muscle of the limb in the mature animal.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Molecular Medicine
Biomedical Sciences Research Institute > Molecular Medicine > Vascular Medicine
ID Code:9477
Deposited By:Dr Christopher Mitchell
Deposited On:23 Jan 2010 16:07
Last Modified:10 Jun 2010 11:01

Repository Staff Only: item control page