Edel, M, Robbins, P, D'Antuono, M, Harvey, J, Papadimitriou, J, Mitchell, Christopher and Dawkins, H (2000) Assessment of endothelial cell proliferation in primary breast carcinoma and its association with axillary lymph node status. BREAST, 9 (1). pp. 28-34. [Journal article]
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The correlation between angiogenesis as assessed by endothelial cell proliferation in blood/lymphatic vessels in primary breast carcinomas, and axillary lymph-node metastasis was studied using a case-control design. Primary breast carcinomas, < 2 cm in diameter, from 26 axillary node positive patients (case), were compared with neoplasms from 45 node-negative patients (control). Vascularity, as assessed by vessel density, and endothelial eel proliferation were measured in a single tissue section using a double immunohistochemical staining technique using MIBI (Ki-67) and FVIII antibodies. No association between vascularity and node status was found (P > 0.70). Node positive breast carcinomas had, on average, significantly smaller proliferating vessels (140+/-7 mu m in perimeter) in the primary lesion when compared with node negative tumours (164+/-7 mu m) in perimeter (P<0.02). In addition, the frequency of relatively small vessels (less than 180 mu m in perimeter) with proliferating endothelium was higher in node positive carcinomas than lymph-node negative neoplasms (P<0.03). This association between node status and the size and frequency of blood/lymphatic vessels with proliferating endothelium in primary carcinoma may have important implications in metastasis. (C) 2000 Harcourt Publishers Ltd.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Biomedical Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Molecular Medicine
Biomedical Sciences Research Institute > Molecular Medicine > Vascular Medicine
|Deposited By:||Professor Christopher Mitchell|
|Deposited On:||23 Jan 2010 16:05|
|Last Modified:||10 Jun 2010 10:59|
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