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Assessment of endothelial cell proliferation in primary breast carcinoma and its association with axillary lymph node status

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Edel, M, Robbins, P, D'Antuono, M, Harvey, J, Papadimitriou, J, Mitchell, Christopher and Dawkins, H (2000) Assessment of endothelial cell proliferation in primary breast carcinoma and its association with axillary lymph node status. BREAST, 9 (1). pp. 28-34. [Journal article]

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Abstract

The correlation between angiogenesis as assessed by endothelial cell proliferation in blood/lymphatic vessels in primary breast carcinomas, and axillary lymph-node metastasis was studied using a case-control design. Primary breast carcinomas, < 2 cm in diameter, from 26 axillary node positive patients (case), were compared with neoplasms from 45 node-negative patients (control). Vascularity, as assessed by vessel density, and endothelial eel proliferation were measured in a single tissue section using a double immunohistochemical staining technique using MIBI (Ki-67) and FVIII antibodies. No association between vascularity and node status was found (P > 0.70). Node positive breast carcinomas had, on average, significantly smaller proliferating vessels (140+/-7 mu m in perimeter) in the primary lesion when compared with node negative tumours (164+/-7 mu m) in perimeter (P<0.02). In addition, the frequency of relatively small vessels (less than 180 mu m in perimeter) with proliferating endothelium was higher in node positive carcinomas than lymph-node negative neoplasms (P<0.03). This association between node status and the size and frequency of blood/lymphatic vessels with proliferating endothelium in primary carcinoma may have important implications in metastasis. (C) 2000 Harcourt Publishers Ltd.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Molecular Medicine
Biomedical Sciences Research Institute > Molecular Medicine > Vascular Medicine
ID Code:9472
Deposited By:Dr Christopher Mitchell
Deposited On:23 Jan 2010 16:05
Last Modified:10 Jun 2010 10:59

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