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Mutagen sensitivity in thymidine kinase- and methyltransferase-deficient human lymphoblastoid cells

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Best, CJ, McKenna, PG and McKelvey-Martin, Valerie (1997) Mutagen sensitivity in thymidine kinase- and methyltransferase-deficient human lymphoblastoid cells. BRITISH JOURNAL OF BIOMEDICAL SCIENCE, 54 (4). pp. 267-272. [Journal article]

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Abstract

In this study the effect of thymidine kinase deficiency on the responses of the human lymphoblastoid cell line Raji to methyl methanesulphonate and mitomycin C was investigated. Mutagen sensitivity was measured in terms of cell survival and mutation to hypoxanthine-guanine phosphoribosyltransferase deficiency. Thymidine kinase-deficient Raji cells showed decreased survival and increased mutant frequency relative to wild-type cells following treatments with each of the mutagens used. It is suggested that this may be due to an imbalance in the supply of deoxyribonucleoside triphosphates to the excision repair process. The role of O-6-methylguanine-DNA methyltransferase in the repair of DNA damage caused by these mutagens is also discussed.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:9258
Deposited By:Professor Valerie McKelvey-Martin
Deposited On:22 Jan 2010 12:27
Last Modified:04 Dec 2012 12:31

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