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The effect of changing intraocular pressure on the corneal and scleral curvatures in the fresh porcine eye

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Pierscionek, K., Asejczyk-Widlicka, M. and Schachar, R. A. (2007) The effect of changing intraocular pressure on the corneal and scleral curvatures in the fresh porcine eye. BRITISH JOURNAL OF OPHTHALMOLOGY, 91 (6). pp. 801-803. [Journal article]

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DOI: 10.1136/bjo.2006.110221

Abstract

Aim: To measure corneal and scleral radii of curvature in response to intraocular pressure (IOP). Methods: Using digital photographic profile images of 16 fresh porcine eyes, the curvatures of the cornea and sclera were determined in response to five consecutive incremental 100 mu l saline intravitreal injections. IOP was measured and ocular rigidity calculated. Elastic moduli of the cornea and sclera were estimated. Results: Intraocular pressure and the radius of curvature of the sclera increased linearly with increasing volume. There was no statistical change in corneal curvature. The elasticity of the cornea and sclera was constant during the 15-50 mm Hg increase in IOP. The estimated range of the elastic moduli of the cornea and sclera were, respectively 0.07-0.29 MPa and 0.2 MPa to 0.5 MPa. The scleral rigidity ranged from 0.0017 to 0.0022. Conclusions: The elastic moduli of the cornea and sclera are independent of IOP. The modulus of elasticity of the sclera is higher than that of the cornea. Elevation of IOP changes the curvature of the sclera but not that of the cornea. Porcine scleral rigidity is similar to human scleral rigidity. Scleral curvature could be a novel method for measuring IOP.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Vision
ID Code:7623
Deposited By:Professor Barbara Pierscionek
Deposited On:18 Jan 2010 09:49
Last Modified:18 Jan 2010 09:49

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