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A randomized trial investigating an iron-rich natural mineral water as a prophylaxis against iron deficiency in pregnancy

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McKenna, D, Spence, D, Haggan, SE, McCrum, E, Dornan, JC and Lappin, TR (2003) A randomized trial investigating an iron-rich natural mineral water as a prophylaxis against iron deficiency in pregnancy. CLINICAL AND LABORATORY HAEMATOLOGY, 25 (2). pp. 99-103. [Journal article]

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Spatone Iron-Plus is a naturally occurring mineral water from Trefriw Wells Spa in Conwy County, North Wales, UK. It contains approximately 0.20 mg of iron per millilitre as ferrous sulphate and has been shown to provide iron in a highly bio-available form. A 24 ml sachet contains approximately 5 mg of iron. Iron deficiency is common in the obstetric population. However, compliance with traditional iron supplements is poor because of gastrointestinal side-effects. We designed a randomized, double-blind, placebo-controlled trial. A total of 102 low-risk antenatal patients, who were noncompliant with routinely prescribed ferrous sulphate tablets, were randomized to receive 48 ml of Spatone water or placebo. The study was conducted between 22 and 28 weeks gestation. Primary outcome measures were compliance, gastrointestinal side-effects and changes in ferritin levels during the trial period. Compliance in the intervention group was 57% compared with 67% in the control group, P = 0.22. Dyspepsia scores, as determined by a recognized and well-validated questionnaire, did not differ between the two groups. During the trial period, mean ferritin levels fell by 24% in the Spatone Iron-Plus group compared with a mean fall of 51% in ferritin levels among the control group, P = 0.016.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Research Institutes and Groups:Institute of Nursing and Health Research
Institute of Nursing and Health Research > Maternal, Fetal and Infant Research
ID Code:7368
Deposited By:Ms Evie Gardner
Deposited On:27 Jan 2010 15:38
Last Modified:18 Oct 2011 15:31

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