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The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Hill, T, Meunier, N, Andriollo-Sanchez, M, Ciarapica, D, Hininger-Favier, I, Polito, A, O'Connor, JM, Coudray, C and Cashman, KD (2005) The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 59 (Suppl. 2). S73-S78. [Journal article]

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DOI: 10.1038/sj.ejcn.1602303

Abstract

Objective: To investigate the relationship between indices of zinc nutritive status and biochemical markers of bone turnover in older adult European subjects. Design: Use of baseline data from a multicentre prospective zinc intervention (ZENITH) study. Setting: Centres in France, Italy and Northern Ireland. Participants: A total of 387 healthy adults, aged 55-87 y. Methods: Zinc intake was assessed by 4-day recall records. Circulating and urinary biochemical zinc status measures were assessed by atomic absorption spectrophometry. Serum bone-specific alkaline phosphatase and osteocalcin were assessed by ELISA and urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) by HPLC. Results: Zinc intake was negatively correlated with urinary Pyr and Dpyr (r= -0.298 and -0.304, respectively; P<0.0001), but was not correlated with bone formation markers. There was a tendency for serum zinc to be negatively correlated with urinary Dpyr (r= -0.211; P = 0.080). Erythrocyte zinc was negatively correlated with serum osteocalcin (r= -0.090; P<0.0001). None of the other correlations were significant. After adjustment for confounder (age, gender and research Centre) the only significant association that remained was between serum osteocalcin and erythrocyte zinc (P = -0.124; P=0.011). Conclusions: There was some, albeit inconsistent, evidence of a relationship between zinc nutritive status and bone turnover in the older adult participants of the ZENITH study.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
ID Code:7187
Deposited By:Professor Jacqueline McCormack
Deposited On:18 Jan 2010 11:35
Last Modified:15 Dec 2011 15:59

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