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Effects of zinc supplementation on cognitive function in healthy middle-aged and older adults: the ZENITH study

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Maylor, Elizabeth A, Simpson, Ellen EA, Secker, David L, Meunier, Nathalie, Andriollo-Sanchez, Maud, Polito, Angela, Stewart-Knox, Barbara, McConville, Christopher, O'Connor, Jacqueline M and Coudray, Charles (2006) Effects of zinc supplementation on cognitive function in healthy middle-aged and older adults: the ZENITH study. BRITISH JOURNAL OF NUTRITION, 96 (4). pp. 752-760. [Journal article]

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DOI: 10.1079/BJN20061911

Abstract

A randomised double-blind placebo-controlled design was employed to investigate the effects of Zn supplementation on cognitive function in 387 healthy adults aged 55-87 years. Several measures of visual memory, working memory, attention and reaction time were obtained using the Cambridge Automated Neuropsychological Test Battery at baseline and then after 3 and 6 months of 0 (placebo), 15 or 30 mg Zn/d. Younger adults (< 70 years) performed significantly better on all tests than older adults (> 70 years), and performance improved with practice on some measures. For two out of eight dependent variables, there were significant interactions indicating a beneficial effect (at 3 months only) of both 15 and 30 mg/d on one measure of spatial working memory and a detrimental effect of 15 mg/d on one measure of attention. Further work is required to establish whether these findings generalise to older adults in poorer mental and physical health and with less adequate Zn intake and status than the present sample.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Biomedical Sciences Research Institute
Psychology Research Institute
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
Psychology Research Institute > Health and Wellbeing
ID Code:7174
Deposited By:Professor Jacqueline McCormack
Deposited On:18 Jan 2010 11:31
Last Modified:15 Dec 2011 15:49

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