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No Antioxidant Beneficial Effect of Zinc Supplementation on Oxidative Stress Markers and Antioxidant Defenses in Middle-Aged and Elderly Subjects: The Zenith Study

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Andriollo-Sanchez, Maud, Hininger-Favier, Isabelle, Meunier, Nathalie, Venneria, Eugenia, O'Connor, JM, Maiani, Giuseppe, Polito, Angela, Bord, Severine, Ferry, Monique, Coudray, Charles and Roussel, Anne-Marie (2008) No Antioxidant Beneficial Effect of Zinc Supplementation on Oxidative Stress Markers and Antioxidant Defenses in Middle-Aged and Elderly Subjects: The Zenith Study. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 27 (4). pp. 463-469. [Journal article]

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Abstract

Objective: The aim of the study was to investigate whether zinc supplementation affects antioxidant status in European middle-aged and elderly people. Design: Multicentre prospective intervention study, randomized, double-blind, placebo-control. Setting: France (Clermont-Ferrand/Theix. and Grenoble), Italy (Rome), Northern Ireland (Coleraine). Subjects: A total of 387 healthy middle-aged (55-70 yrs) and free-living older aged (70-85 yrs) subjects were randomly allocated to three groups: 0, 15 or 30 mg zinc gluconate/d in addition to usual dietary intake during 6 months. Methods: Oxidative stress status was evaluated by measurement of protein oxidation (plasma thiol groups), lipid peroxidation (plasma thio-barbituric acid reactants, TBARS), whole blood glutathione levels, erythrocyte copper/zinc superoxide dismutase activity and plasma antioxidant status (ferric reducing antioxidant power assay), at baseline and after 3 and 6 months. Results: Zinc supplementation did not alter oxidative stress markers and antioxidant defenses in elderly. after 3 or 6 months, except an increase in Cu/Zn superoxide dismutase activity. Conclusions: In apparently healthy free living elderly people, a single zinc supplementation had no effects on oxidative stress status.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
ID Code:7170
Deposited By:Professor Jacqueline McCormack
Deposited On:18 Jan 2010 11:28
Last Modified:15 Dec 2011 15:40

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