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Congenital hydronephrosis - Prenatal diagnosis and epidemiology in Europe

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Garne, Ester, Loane, Maria, Wellesley, Diana, Barisic, Ingeborg and EUROCAT, Working Group (2009) Congenital hydronephrosis - Prenatal diagnosis and epidemiology in Europe. Journal of Pediatric Urology, 5 (1). pp. 47-52. [Journal article]

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URL: http://www.jpurol.com/article/S1477-5131(08)00385-9/abstract

DOI: 10.1016/j.jpurol.2008.08.010

Abstract

ObjectiveTo describe prevalence, prenatal diagnosis and epidemiology of congenital hydronephrosis (CH) in Europe.Material and methodData from a large European database for surveillance of congenital malformations (EUROCAT). The 20 participating registries are all based on multiple sources of information and include information about livebirths, fetal deaths with gestational age ≥20 weeks and terminations of pregnancy after prenatal diagnosis of malformations. Included were all cases with CH and born 1995–2004.ResultsThere were 3648 cases with CH giving an overall prevalence of 11.5 cases per 10,000 births. The large majority of cases were livebirths (3506, 96% of total) and only 17 cases were fetal deaths and 120 were terminations of pregnancy. Almost all livebirths were alive 1 week after birth. Boys accounted for 72% of all cases. A high proportion of the cases (86%) had an isolated renal malformation. There were large regional differences in prevalence of CH ranging from 2 to 29 per 10,000 births. There was little regional variation in the prevalence of postnatally diagnosed cases while there were large regional differences in prevalence of prenatally diagnosed cases.ConclusionCases with CH are mainly livebirths, boys and survive the first week after birth. The large difference in prevalence seems to be related to the availability of prenatal screening in the region. The impact of over-diagnosis and potential over-treatment in regions with high prevalence or under-diagnosis with implications for renal function later in life in regions with low prevalence needs further investigation.Keywords: Congenital hydronephrosis, Prevalence, Prenatal diagnosis, Epidemiologya Paediatric Department, Kolding Hospital, 6000 Kolding, Denmarkb University of Ulster, Belfast, UKc Princess Anne Hospital, Southampton, UKd Children's University Hospital, Zagreb, CroatiaCorresponding author. Tel.: +45 7626 2219; fax: +45 7636 3474.e See appendix for EUROCAT Working Group.PII: S1477-5131(08)00385-9doi:10.1016/j.jpurol.2008.08.010© 2008 Journal of Pediatric Urology Company. Published by Elsevier Inc. All rights reserved. 13 of 19

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Nursing
Research Institutes and Groups:Institute of Nursing and Health Research
Institute of Nursing and Health Research > Maternal, Fetal and Infant Research
ID Code:6615
Deposited By:Ms Maria Loane
Deposited On:03 Feb 2010 14:41
Last Modified:18 Oct 2011 14:01

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