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Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Sun, N, McMullan, M, Papakonstantinou, P, Gao, H, Zhang, XX, Mihailovic, D and Li, MX (2008) Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten. ANALYTICAL CHEMISTRY, 80 (10). pp. 3593-3597. [Journal article]

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DOI: 10.1021/ac7024893

Abstract

We demonstrate a novel and highly sensitive electrochemical detection of estrone based on an immunosensor platform, composed of bioassembled nanocircuits of Mo6S9-xIx nanowires (MoSI NWs) covalently connected to anti-estrone antibodies. The one-step, label-free, and quantitative detection of estrone is realized by employing the [Ru(NH3)(6)](3+/2+) redox ions to sense anti-estrone antibody and estrone interactions. The MoSI NWs/anti-estrone antibody nanocircuit architectures provide an amplification and conductive pathway for the specific electrochemical sensing of estrone hapten. A detection limit of 1.4 pg.mL(-1) was achieved in contrast to previous electrochemical techniques in which the sensitivity was limited to the nanomolar range.

Item Type:Journal article
Faculties and Schools:Faculty of Computing & Engineering
Faculty of Computing & Engineering > School of Engineering
Research Institutes and Groups:Engineering Research Institute
Engineering Research Institute > Nanotechnology & Integrated BioEngineering Centre (NIBEC)
ID Code:6395
Deposited By:Professor Pagona Papakonstantinou
Deposited On:13 Jan 2010 09:54
Last Modified:18 Aug 2011 11:57

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