Smyth, T., Ramachandran, V. N. and Smyth, W. F. (2009) A study of the antimicrobial activity of selected naturally occurring and synthetic coumarins. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 33 (5). pp. 421-426. [Journal article]
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The antimicrobial activities of 43 naturally occurring and synthetic coumarins were studied. Using a microtitre assay developed in-house, a range of Gram-positive and Gram-negative bacteria, including a hospital isolate of methicillin-resistant Staphylococcus aureus (MRSA), were utilised. The coumarins exhibiting good bioactivity (i.e. a lowminimum inhibitory concentration) against two S. aureus strains were then assessed for their antimicrobial activities against a range of eight clinically isolated MRSA strains. The study showed that nearly one-half of the tested compounds displayed antimicrobial activity. Sixteen of these coumarins also possessed resistance-modifying activity, which reversed the resistance mechanism in MRSA allowing the antimicrobial oxacillin to exert an enhanced effect against an MRSA hospital strain. When tested in combination with oxacillin, 8-iodo-5,7-dihydroxycoumarin (32) had a similar activity to vancomycin, which is the current drug of choice for the treatment of MRSA infections. (C) 2008 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Biomedical Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
|Deposited By:||Prof W.Franklin Smyth|
|Deposited On:||11 Jan 2010 11:46|
|Last Modified:||04 May 2012 09:20|
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