McMahon, MAS, Blair, Ian S., Moore, John E. and McDowell, DA (2007) Habituation to sub-lethal concentrations of tea tree oil (Melaleuca alternifolia) is associated with reduced susceptibility to antibiotics in human pathogens. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 59 (1). pp. 125-127. [Journal article]
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Objectives: To investigate the effect of sub-lethal challenge with tea tree oil (TTO) on the antibiotic susceptibility profiles of significant human pathogens and commensals. Methods: The study compared the antibiotic susceptibility (Etest) patterns of Escherichia coli, Staphylococcus aureus/methicillin-resistant S. aureus (MRSA) and Salmonella spp. after broth culture for 72 h in the presence or absence of sub-lethal concentrations of TTO (0.25%, 0.25% and 0.1%). Results: All habituated cultures (exposed to sub-lethal concentrations of TTO) displayed reduced susceptibility to a range of clinically relevant antibiotics compared with non-habituated (control) cultures. Conclusions: Although TTO may be an effective antimicrobial agent when appropriately used at bactericidal concentrations, its application at sub-lethal concentrations may contribute to the development of antibiotic resistance in human pathogens.
|Item Type:||Journal article|
|Keywords:||antibiotic susceptibility profiles; MRSA; antibacterial agents|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Health Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Infection and Immunity/Microbiology
|Deposited By:||Dr Ann McMahon|
|Deposited On:||13 Jan 2010 11:55|
|Last Modified:||01 Mar 2012 15:00|
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