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Comparison of the effect of ciprofloxacin and Tazocin (R) on the incidence of meticillin-resistant Staphylococcus aureus (MRSA) in an Intensive Care Unit

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Aldeyab, Mamoon A., Hughes, Carmel M., Kearney, Mary P., Scott, Michael G., McDowell, DA, Hanley, Joanne, McMahon, MAS, Elshibly, Salah M., Bailie, Ronald and McElnay, James C. (2008) Comparison of the effect of ciprofloxacin and Tazocin (R) on the incidence of meticillin-resistant Staphylococcus aureus (MRSA) in an Intensive Care Unit. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 32 (6). pp. 499-504. [Journal article]

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DOI: 10.1016/j.ijantimicag.2008.06.021


Meticillin-resistant Staphylococcus aureus (MRSA) is a very significant agent of recalcitrant healthcare-associated infections. A major risk of acquiring such infections is thought to be modulated by the use of particular antimicrobial therapies. The aim of this research was to evaluate prospectively the impact of using either ciprofloxacin or Tazocin (R) (piperacillin + tazobactam) on the incidence of MRSA in an Intensive Care Unit (ICU). The 1-year (2 x 6 months) cross-over study was carried out in a medium-sized (426 beds) teaching hospital. During the first 6-month period, ciprofloxacin was used as the first-line broad-spectrum antibiotic therapy of choice. During the second 6-month period, Tazocin (R) was used as first-line therapy. The incidence of hospital-acquired MRSA (i.e. colonised and/or infected) and rates of compliance of the ICU healthcare workers to optimal hand hygiene practices were recorded throughout the study. The study observed no statistically significant differences (P = 0.1) between MRSA incidence rates in the ICU during the ciprofloxacin (4.4/1000 bed-days) or Tazocin (R) (11.4/1000 bed- days) arms of the study. Interestingly, observing healthcare workers' hand hygiene practices throughout the entire study showed that healthcare workers adhered to these practices 59.2% of the time during the ciprofloxacin arm and 66.0% during the Tazocin (R) arm. The low incidence rates within the unit demonstrated the importance of infection control in limiting the spread of MRSA despite the extensive use of antibiotics in a high-risk setting. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.

Item Type:Journal article
Keywords:Hospital-acquired MRSA; Antibiotic resistance; Infection control practices
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Health Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Infection and Immunity/Microbiology
ID Code:6107
Deposited By:Dr Ann McMahon
Deposited On:13 Jan 2010 11:38
Last Modified:01 Mar 2012 15:00

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