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Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer cells in vitro

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Magee, Pamela, McGlynn, H and Rowland, IR (2004) Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer cells in vitro. CANCER LETTERS, 208 (1). pp. 35-41. [Journal article]

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DOI: 10.1016/j.canlet.2003.11.012

Abstract

Metastasis is a major cause of morbidity and mortality in breast cancer with tumour cell invasion playing a crucial role in the metastatic process. The effects of a panel of phytoestrogens, including isoflavones and lignans on the invasion of a breast cancer cell-line (MDA-MB-231) through Matrigel were assessed. Genistein, glycitein, daidzein, equol, O-Desmethylangolensin (O-Dma) and coumestrol exerted a potent inhibitory effect on cell invasion (e.g. inhibition of 41.7 +/- 15% (P = 0.007); coumestrol (10 muM)). In contrast the lignans exerted minimal effects on invasion. Inhibition of invasion induced by the phytoestrogens occurred without affecting cell viability, highlighting the possible chemoprotective effects of these compounds. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
ID Code:5667
Deposited By:Dr Pamela Magee
Deposited On:13 Jan 2010 11:41
Last Modified:13 Jan 2010 11:41

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