Magee, Pamela, McGlynn, H and Rowland, IR (2004) Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer cells in vitro. CANCER LETTERS, 208 (1). pp. 35-41. [Journal article]
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Metastasis is a major cause of morbidity and mortality in breast cancer with tumour cell invasion playing a crucial role in the metastatic process. The effects of a panel of phytoestrogens, including isoflavones and lignans on the invasion of a breast cancer cell-line (MDA-MB-231) through Matrigel were assessed. Genistein, glycitein, daidzein, equol, O-Desmethylangolensin (O-Dma) and coumestrol exerted a potent inhibitory effect on cell invasion (e.g. inhibition of 41.7 +/- 15% (P = 0.007); coumestrol (10 muM)). In contrast the lignans exerted minimal effects on invasion. Inhibition of invasion induced by the phytoestrogens occurred without affecting cell viability, highlighting the possible chemoprotective effects of these compounds. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Biomedical Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
|Deposited By:||Dr Pamela Magee|
|Deposited On:||13 Jan 2010 11:41|
|Last Modified:||13 Jan 2010 11:41|
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