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Determinants of pp-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Sanz-Gallardo, MI, Guallar, E, Van't Veer, P, Longnecker, MP, Strain, JJ, Martin, BC, Kardinaal, AFM, Fernandez-Crehuet, J, Thamm, M, Kohlmeier, L, Kok, FJ and Martin-Moreno, JM (1999) Determinants of pp-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities. ARCHIVES OF ENVIRONMENTAL HEALTH, 54 (4). pp. 277-283. [Journal article]

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Abstract

To identify the determinants of pp-dichlorodiphenyldichloroethane (pp-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and pp-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p,p'-DDE concentration was 1.66 mu g/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log(10)(pp-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9% of the overall variability of log(10)(pp-DDE), In our subjects, adipose tissue pp-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p,p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
ID Code:5246
Deposited By:Mrs Alison Deehan
Deposited On:14 Jan 2010 14:57
Last Modified:14 Jan 2010 14:57

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