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A study of the electrospray ionisation of pharmacologically significant 1,4-benzodiazepines and their subsequent fragmentation using an ion-trap mass spectrometer

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Smyth, Franklin, McClean, Stephen and Ramachandran, V. N. (2000) A study of the electrospray ionisation of pharmacologically significant 1,4-benzodiazepines and their subsequent fragmentation using an ion-trap mass spectrometer. Rapid communications in mass spectrometry : RCM, 14 (21). pp. 2061-2069. [Journal article]

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Abstract

The electrospray ionisation (ESI) of sixteen pharmacologically significant 1,4-benzodiazepines and their subsequent fragmentation using an ion-trap mass spectrometer have been investigated. Sequential product ion fragmentation experiments (MSn) were performed in order to elucidate the degradation pathways for these compounds. Comparisons were also made between these ESI spectra and those obtained under electron impact (EI) conditions. The data presented in this paper provide useful information on the effect of different substituents on the ionisation/fragmentation processes and can be used in the characterisation of this important class of drugs and their metabolites.

Item Type:Journal article
Keywords:Benzodiazepines/analysis/chemistry/metabolism; Molecular Structure; Spectrometry, Mass, Electrospray Ionization/methods
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:5095
Deposited By:Dr Stephen McClean
Deposited On:05 Jan 2010 14:39
Last Modified:04 May 2012 09:20

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