McClean, Stephen, Robinson, R. C., Shaw, C. and Smyth, Franklin (2002) Characterisation and determination of indole alkaloids in frog-skin secretions by electrospray ionisation ion trap mass spectrometry. Rapid communications in mass spectrometry : RCM, 16 (5). pp. 346-354. [Journal article]
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The characterisation of selected indole alkaloids in a quadrupole ion trap mass spectrometer is presented. Fragmentation profiles for tryptamine, 5-hydroxytryptamine (5-HT), N'-methyl 5-hydroxytryptamine (N'-methyl 5-HT), N',N'-dimethyl 5-hydroxytryptamine (bufotenine), N',N',N'-trimethyl 5-hydroxytryptamine (5-HTQ), and N',N'-dimethyl 5-methoxytryptamine (5-MeODMT) are presented with proposed structures given for each product ion observed. Such MS(n) experiments can be used to differentiate the isobaric molecular ions of the compounds 5-HTQ (M(+)) and 5-MeODMT (MH(+)). The quantitative determination of certain indole alkaloids in the skin secretions of the Australian Golden Bell frog, Litoria aurea, by LC/ESI-ion trap MS is also presented. The concentrations of 5-HT, N'-methyl 5-HT and 5-HTQ were found to be 2.68, 0.26 and 0.54 microg per mg of skin secretion, respectively.
|Item Type:||Journal article|
|Keywords:||Alkaloids/analysis; Animals; Anura; Chromatography, Liquid; Indicators and Reagents; Indoles/analysis; Serotonin/analysis; Skin/chemistry; Spectrometry, Mass, Electrospray Ionization; Tryptamines/analysis|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Biomedical Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
|Deposited By:||Dr Stephen McClean|
|Deposited On:||06 Jan 2010 16:15|
|Last Modified:||04 May 2012 09:20|
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