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Gene-directed enzyme prodrug therapy: A current assessment

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

McKeown, SR, Ward, C and Robson, T (2004) Gene-directed enzyme prodrug therapy: A current assessment. CURRENT OPINION IN MOLECULAR THERAPEUTICS, 6 (4). pp. 421-435. [Journal article]

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Abstract

Gene-directed enzyme prodrug therapy involves tumor-specific delivery of a gene encoding a drug-metabolizing enzyme allowing metabolism of a non-toxic prodrug to a toxic species directly within tumor cells. This review covers the wide range of enzyme-prodrug combinations currently under preclinical and clinical investigation. Issues of tumor specificity and enhanced cytotoxicity through bystander effects will be discussed.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:4317
Deposited By:Professor Stephanie McKeown
Deposited On:21 Dec 2009 12:02
Last Modified:01 Jun 2011 16:49

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