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Dose-response effects of a novel fat emulsion (Olibra (TM))on energy and macronutrient intakes up to 36 h post-consumption

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Burns, AA, Livingstone, Barbara, Welch, Rob, Dunne, A and Rowland, IR (2002) Dose-response effects of a novel fat emulsion (Olibra (TM))on energy and macronutrient intakes up to 36 h post-consumption. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 56 (4). pp. 368-377. [Journal article]

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DOI: 10.1038/sj/ejcn/1601326

Abstract

Objective: To investigate the dose-response effects of a novel fat emulsion (Olibra(TM)) on energy and macronutrient intakes up to 36 h post-consumption in non-overweight subjects. Design: A single-blind, placebo-controlled, within-subject cross-over design was used. Setting: Metabolic suite of the University of Ulster, Coleraine. Subjects: Fifty subjects (30 female, 20 mate) from the student and staff population of the University of Ulster, Coleraine. Interventions: Subjects were given in random order, 7 days apart, a 200 g portion of yoghurt containing a total of 15 g of fat, which varied in quantity of Olibra(TM) fat (0, 2, 4, 6 g) at 09:00 h. At 13:00 h subjects were given ad libitum access to a range of foods. Amounts of food consumed were measured by covert pre- and post-consumption weighing of individual serving dishes. For the remainder of the day and the following 24 h, subjects weighed and recorded all food intakes. Results: Relative to the control yoghurt, mean energy (7.42 vs 5.83, 5,60, 5.24 MJ), fat (97.4 vs 74.4, 74.2, 67.5 g; 48.8 vs 46.8, 48.9, 47.6% energy), protein (59.1 vs 50.0, 44.0, 40.8 g; 13.2 vs 13.9, 12.9, 12.8% energy), and carbohydrate (171.5 vs 140.9, 130.2, 126.0 g; 38.0 vs 39.3, 38.2, 39.6% energy), intakes were progressively reduced with increasing doses of Olibra(TM) fat in the total group (P < 0.001). A similar response was observed in the female group up to 4 g (P < 0.001) and in the male group after 2 and 6 g (P < 0.05). Energy and macronutrient intakes for the remainder of each study day and over the following 24 h were significantly lower after all dose levels compared to the control (P < 0.001). Conclusion: The results suggest that Olibra(TM) fat reduced the effect of overeating during an ad libitum lunch meal and subsequent food intake up to 36 h post-consumption. Sponsorship: Scotia Pharmaceuticals Limited.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
ID Code:4232
Deposited By:Dr Tracy McCaffrey
Deposited On:13 Jan 2010 14:45
Last Modified:01 Nov 2011 11:18

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