Ulster University Logo

Ulster Institutional Repository

Strategies for the prevention of microbial biofilm formation on silicone rubber voice prostheses

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Rodrigues, Ligia, Banat, Ibrahim, Teixeira, Jose and Oliveira, Rosario (2007) Strategies for the prevention of microbial biofilm formation on silicone rubber voice prostheses. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 81B (2). pp. 358-370. [Journal article]

Full text not available from this repository.

DOI: 10.1002/jbm.b.30673

Abstract

Total laryngectomy, a surgical treatment for extensive cancer of larynx, which alters swallowing and respiration in patients, is followed up with a surgical voice restoration procedure comprising tracheoesophageal puncture techniques with insertion of a ``voice prosthesis'' to improve successful voice rehabilitation. However, microbial colonization is a major drawback of these devices. Antimicrobials are usually used to prevent the colonization of silicone rubber voice prostheses by microorganisms. However, long-term medication induces the development of resistant strains with all associated risks and the development of alternative prophylactic and therapeutic agents, including probiotics and biosurfactants, have been suggested. The inhibition of microbial growth on surfaces can also be achieved by several other techniques involving the modification of physicochemical properties of the biomaterial surface or the covalently binding of antimicrobial agents to the biomaterial surface. An overview of the different approaches investigated to date and future perspectives to reduce the frequent replacements of voice prostheses in laryngectomized patients through microbial biofilm retardation is presented and discussed. (c) 2006 Wiley Periodicals, Inc.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:4128
Deposited By:Professor Ibrahim Banat
Deposited On:08 Jan 2010 15:02
Last Modified:16 May 2012 11:31

Repository Staff Only: item control page