Singh, Narinder, Kaur, Navneet, Mulrooney, Ray C. and Callan, John F. (2008) A ratiometric fluorescent probe for magnesium employing excited state intramolecular proton transfer. TETRAHEDRON LETTERS, 49 (47). pp. 6690-6692. [Journal article]
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A simple fluorescent sensor has been developed for the ratiometric recognition of Mg2+ in semi-aqueous solution at pH 7.0. The sensor, a Schiff base, undergoes Excited State Intramolecular Proton Transfer (ESIPT) to generate a keto tautomer with proficient Mg2+ binding capability. The sensor displays good selectivity over other metal ions including alkali/alkali earth ions and can measure Mg2+ ion concentration between 2.0 and 30.0 mu M. The binding stoichiometry was established as 2:1 (host:guest) with an association constant (K-21) of (1.4 +/- 0.1) x 10(4) m(-2). The sensor could potentially be used to detect conditions such as hypermagnesaemia. (C) 2008 Elsevier Ltd. All rights reserved.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
|Deposited By:||Professor John Callan|
|Deposited On:||05 Jan 2010 11:49|
|Last Modified:||19 Nov 2012 15:25|
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