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A ratiometric fluorescent probe for magnesium employing excited state intramolecular proton transfer

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Singh, Narinder, Kaur, Navneet, Mulrooney, Ray C. and Callan, John F. (2008) A ratiometric fluorescent probe for magnesium employing excited state intramolecular proton transfer. TETRAHEDRON LETTERS, 49 (47). pp. 6690-6692. [Journal article]

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DOI: 10.1016/j.tetlet.2008.09.052

Abstract

A simple fluorescent sensor has been developed for the ratiometric recognition of Mg2+ in semi-aqueous solution at pH 7.0. The sensor, a Schiff base, undergoes Excited State Intramolecular Proton Transfer (ESIPT) to generate a keto tautomer with proficient Mg2+ binding capability. The sensor displays good selectivity over other metal ions including alkali/alkali earth ions and can measure Mg2+ ion concentration between 2.0 and 30.0 mu M. The binding stoichiometry was established as 2:1 (host:guest) with an association constant (K-21) of (1.4 +/- 0.1) x 10(4) m(-2). The sensor could potentially be used to detect conditions such as hypermagnesaemia. (C) 2008 Elsevier Ltd. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:4065
Deposited By:Professor John Callan
Deposited On:05 Jan 2010 11:49
Last Modified:19 Nov 2012 15:25

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