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Electrokinetic dispersion of a cancer chemotherapeutic drug for the treatment of solid tumours

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Nomikou, Nikolitsa and McHale, Anthony (2009) Electrokinetic dispersion of a cancer chemotherapeutic drug for the treatment of solid tumours. CANCER LETTERS, 279 (2). pp. 202-208. [Journal article]

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DOI: 10.1016/j.canlet.2009.01.038


Compromised turnout vascularisation presents a significant challenge to chemotherapeutic-based treatment of solid tumours. In this study we use subtle electric field characteristics to facilitate electrokinetic movement of a cancer chemotherapeutic agent in an ionically complex environment. We demonstrate that such an approach can be exploited to facilitate the electrokinetic movement of camptothecin from a peritumoural site through otherwise relatively impermeable turnout tissues. Here we demonstrate enhanced antitumour effects using this approach in a pre-clinical model for solid tumours and suggest one possible therapeutic application of the approach in the treatment of lung cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:3977
Deposited By:Professor Anthony McHale
Deposited On:18 Dec 2009 14:40
Last Modified:04 Dec 2012 11:18

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