McEnery, O., Lucas, L., Ma, YingLiang, Morrow, PJ, Mitchell, Christopher and Saetzler, Kurt (2006) A fast, robust and scale-independent approach to estimate vessel diameters in intravital fluorescence microscopy images. In: Biomedical Imaging: Macro to Nano, 2006. 3rd IEEE International Symposium on. UNSPECIFIED. 4 pp. [Conference contribution]
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Analyzing dynamic biological systems, such as blood vessel growth in healing wounds or tumour development, requires high spatial and temporal resolution. Intravital fluorescence microscopy allows for longitudinal subcellular imaging, but it requires the use of advanced image analysis tools in order to quantitatively extract the relevant parameters or the topology of the underlying network structure to subsequently model and simulate such a system mathematically. We will present a fast and robust approach that estimates the vessel diameter with a low coefficient of error < 6% in settings that are typical for such in-vivo imaging scenarios with a low signal-to-noise ratio and often sub-optimal and uneven background illumination. The generated vessel network is geometrically cleansed for an optimal topological representation.
|Item Type:||Conference contribution (Poster)|
|Keywords:||biomedical optical imaging, blood vessels, fluorescence, image representation, medical image processing, optical microscopy, advanced image analysis tools, blood vessel growth, dynamic biological systems, healing wounds, high spatial resolution, high temporal resolution, in-vivo imaging, intravital fluorescence microscopy images, longitudinal subcellular imaging, low signal-to-noise ratio, optimal topological representation, suboptimal background illumination, tumour development, uneven background illumination, vessel diameter estimation|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Biomedical Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Computer Science Research Institute
Biomedical Sciences Research Institute > Molecular Medicine
Biomedical Sciences Research Institute > Molecular Medicine > Neuroscience & Neurodegenerative Diseases
Biomedical Sciences Research Institute > Molecular Medicine > Vascular Medicine
|Deposited By:||Dr Kurt Saetzler|
|Deposited On:||01 Feb 2010 10:20|
|Last Modified:||24 Mar 2011 11:32|
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