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Role of mammalian Lignans in the prevention and treatment of prostate cancer

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

McCann, MJ, Gill, Chris, McGlynn, H and Rowland, IR (2005) Role of mammalian Lignans in the prevention and treatment of prostate cancer. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 52 (1). pp. 1-14. [Journal article]

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Abstract

Prostate cancer is poised to become the most prevalent male cancer in the Western world. In Japan and China, incidence rates are almost 10-fold less those reported in the United States and the European Union. Epidemiological data suggest that environmental factors. such as diet can. significantly influence the incidence and `Mortality of prostate cancer The differences in lifestyle between East and West are one of the major risk factors for developing prostate cancer Traditional Japanese and Chinese diets are rich in foods containing phytoestrogent. c compounds, whereas the Western diet is a poor source of these phytochemicals. The lignan phytoestrogens are the most widely occurring of these compounds. In vitro and in vivo reports in the literature indicate that lignans have the capacity to affect the pathogenesis of prostate cancer However their precise mechanism of action in prostate carcinogenesis remains unclear This article outlines the possible role of lignans in prostate cancer by reviewing the current in vitro and in `vivo evidence for their anticancer activities. The intriguing concept that lignans may play a role in the prevention and treatment of prostate cancer over the lifetime of an. individual is discussed.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
ID Code:3748
Deposited By:Dr Chris Gill
Deposited On:17 Dec 2009 13:58
Last Modified:01 Nov 2011 11:46

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