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DIFFERENTIAL-PULSE POLAROGRAPHIC STUDY OF THE DEGRADATION OF H+/K+ ATPASE INHIBITORS SK-AND-F-95601 AND OMEPRAZOLE IN ACIDIC MEDIA AND THE SUBSEQUENT REACTIONS WITH THIOLS

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McClean, Stephen, O'KANE, E, RAMACHANDRAN, VN and Smyth, Franklin (1994) DIFFERENTIAL-PULSE POLAROGRAPHIC STUDY OF THE DEGRADATION OF H+/K+ ATPASE INHIBITORS SK-AND-F-95601 AND OMEPRAZOLE IN ACIDIC MEDIA AND THE SUBSEQUENT REACTIONS WITH THIOLS. ANALYTICA CHIMICA ACTA, 292 (1-2). pp. 81-89. [Journal article]

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Abstract

Differential pulse polarography (DPP) has been used to monitor the degradation of benzimidazole sulphoxide antiulcer drugs SK&F 95601 and omeprazole in 10(-2) mol dm(-3) HCl to two main products, i.e., the sulphenamide and the benzimidazole sulphide. It is also used to follow the reactions of 2-mercaptoethanol with the respective products of these degradations, as simulations of their believed reactions in vivo. These reactions are also followed by UV spectrophotometry, spectrofluorimetry and liquid chromatography. DPP can also be used to selectively determine nanomolar concentrations of these antiulcer drugs and their degradation products, of value in formulation and body fluid analysis.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:3728
Deposited By:Prof W.Franklin Smyth
Deposited On:12 Jan 2010 09:38
Last Modified:04 May 2012 09:19

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