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A STUDY OF THE DIFFERENTIAL-PULSE POLAROGRAPHIC AND STRIPPING VOLTAMETRIC BEHAVIOR OF THE H+/K+ ATPASE INHIBITOR SK-AND-F-95601 AND ITS DEGRADATION PRODUCTS

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

McClean, Stephen, MAXWELL, T, RAMACHANDRAN, VN, O'KANE, E and Smyth, Franklin (1994) A STUDY OF THE DIFFERENTIAL-PULSE POLAROGRAPHIC AND STRIPPING VOLTAMETRIC BEHAVIOR OF THE H+/K+ ATPASE INHIBITOR SK-AND-F-95601 AND ITS DEGRADATION PRODUCTS. ELECTROANALYSIS, 6 (11-12). pp. 996-1003. [Journal article]

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Abstract

The differential pulse polarographic (DPP) behavior of SK&F 95601 (I) has been studied in the pH range 0 to 14. At pH less than or equal to 2, (I) rapidly degrades into the sulfenamide (D-1(I)) and sulfide (D-2(I)), which are both reduced by 2e(-) processes, the former being subject to strong reactant adsorption. SK&F 95601 itself is reduced in a 4e process up to pH10, and either pK(2) or pK(3) values, determined spectrophotometrically, are manifested polarographically at neutral pH. A pK(5) value of 9.0 corresponding to the benzimidazole N-H group deprotonation is manifested polarographically with a pK'(5) value of ca. 11. SK&F 95601 and its degradation products D-1(I), degraded D-1(I), and D-2(I) can all be determined by adsorptive stripping voltammetry (AdSV) with limit of detections (LODs) of 10(-8) mol dm(-3), except for the latter molecule with an LOD of 10(-7) mol dm(-3). These LODs are superior to those determined by DPP. Mixtures of these molecules can also be resolved with similar LODs. Cd2+ can be determined by ASV with a superior LOD in the presence of (I), i.e., 0.08 ppb as compared to 0.57 ppb in its absence, due to chelation phenomena.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:3727
Deposited By:Prof W.Franklin Smyth
Deposited On:12 Jan 2010 09:38
Last Modified:04 May 2012 09:20

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