Ulster University Logo

Ulster Institutional Repository

The assessment of platelet derived growth factor concentration in post myocardial infarction and stable angina patients

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Wallace, Julie, Freeburn, JC, Gilmore, WS, Sinnamon, DG, Craig, BM, McNally, RJ and Strain, JJ (1998) The assessment of platelet derived growth factor concentration in post myocardial infarction and stable angina patients. ANNALS OF CLINICAL BIOCHEMISTRY, 35 (Part 2). pp. 236-241. [Journal article]

Full text not available from this repository.

Abstract

Platelet derived growth factor (PDGF) has been implicated in the pathogenesis of atherosclerosis. PDGF is released by aggregating platelets and monocytes which gather around sites of arterial injury. In the study reported here the concentration of plasma PDGF was measured in post myocardial infarction (MI) patients (n = 28). angina patients (n = 25), and control subjects (n = 27), Venous blood samples were taken and the concentration of PDGF determined by an enzyme linked immunosorbent assay (ELISA). Plasma PDGF concentrations were significantly higher ill the post MI group compared to both the control and angina groups (P less than or equal to 0.05). The increase in PDGF concentration may be due to increased activation of platelets or monocytes since these two cells are major sources of plasma PDGF, High concentrations of PDGF in the circulation could further accelerate the progression of the disease.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
ID Code:3604
Deposited By:Dr Julie Wallace
Deposited On:15 Dec 2009 15:44
Last Modified:11 Feb 2013 16:16

Repository Staff Only: item control page