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Whole blood analysis of phagocytosis, apoptosis, cytokine production, and leukocyte subsets in healthy older men and women: The ZENITH study

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Hodkinson, Clare F, O'Connor, Jacqueline, Alexander, H Denis, Bradbury, Ian, Bonham, Maxine P, Hannigan, BM, Gilmore, William S, Strain, JJ and Wallace, Julie (2006) Whole blood analysis of phagocytosis, apoptosis, cytokine production, and leukocyte subsets in healthy older men and women: The ZENITH study. Journals of Gerontology Series A - Biological Sciences and Medical Sciences, 61 (9). pp. 907-917. [Journal article]

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Abstract

Few studies to date have examined age-related changes in markers of immune status in healthy older individuals. The immune status of 93 healthy individuals aged 55-70 years was assessed by two- and three-color flow cytometry and biochemical analysis. There were significant age effects (p <= .05) on monocyte phagocytic activity and cluster of differentiation (CD) 3/human leukocyte antigen-D-related (HLA-DR) late-activated T lymphocytes (% expression). There was a significant (p <= 0.1) Age X Sex interaction in absolute counts (X 10(9)/L) of CD3/CD8 total cytotoxic T lymphocytes (CTL), the CD4 T-helper to CD8 CTL ratio, the CD3/CD4/CD45RA naive T helper to CD3/CD4/CD45RO memory T helper lymphocyte ratio, and interleukin (1L)-1 beta (% expression) by activated monocytes. The study shows that alterations in markers of immune status occur between 55 and 70 years, and provides reference values for the lymphocyte measures in healthy men and postmenopausal women in this age group. The study further highlights the need for sex-specific reference ranges for such markers.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
ID Code:3575
Deposited By:Dr Julie Wallace
Deposited On:15 Dec 2009 15:27
Last Modified:11 Feb 2013 15:58

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