Hodkinson, Clare F, McCann, Mary, Alexander, H Denis, Bradbury, Ian, Robson, Paula J, Bonham, Maxine P, O'Connor, Jacqueline, Coudray, Charles, Strain, JJ and Wallace, Julie (2007) Effect of zinc supplementation on the immune status of healthy older individuals aged 55-70 years: The ZENITH study. Journals of Gerontology Series A - Biological Sciences and Medical Sciences, 62 (6). pp. 598-608. [Journal article]
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Aging is associated with alterations in the immune system, effects which may be exacerbated by inadequate zinc (Zn) status. We examined the relationship between Zn status and markers of immunity and the effect of supplementation with 15 mg or 30 mg Zn/d for 6 months on immune status in healthy individuals. Zn status was assessed by dietary intake and biochemical indices. Immune status was assessed by multiple flow cytometric methods. At baseline, Zn concentration was positively associated with lymphocyte subpopulation counts and T-lymphocyte activation. Zn supplementation of 30 mg/d significantly lowered B-lymphocyte count, albeit at month 3 only. Lower doses of Zn (15 mg Zn/d) significantly increased the ratio of CD4 to CD8 T lymphocytes at month 6. Overall, these findings suggest that total Zn intake (diet plus supplementation) of up to 40 mg Zn/d do not have significant long-term effects on immune status in apparently healthy persons aged 55-70 years.
|Item Type:||Journal article|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > School of Biomedical Sciences
|Research Institutes and Groups:||Biomedical Sciences Research Institute|
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
|Deposited By:||Dr Julie Wallace|
|Deposited On:||15 Dec 2009 14:56|
|Last Modified:||11 Feb 2013 15:51|
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