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Estimation of the dietary requirement for vitamin D in free-living adults ≥64 y of age

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Cashman, Kevin D., Wallace, Julie, Horigan, Geraldine, Hill, Tom R., Barnes, Maria S., Lucey, Alice J., Bonham, Maxine P., Taylor, Nicola, Duffy, Emeir M., Seamans, Kelly, Muldowney, Siobhan, FitzGerald, Anthony P., Flynn, Albert, Strain, JJ and Kiely, Mairead (2009) Estimation of the dietary requirement for vitamin D in free-living adults ≥64 y of age. AMERICAN JOURNAL OF CLINICAL NUTRITION, 89 (5). pp. 1366-1374. [Journal article]

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DOI: 10.3945/ajcn.2008.27334

Abstract

Background: Older adults may be more prone to developing vitamin D deficiency than younger adults. Dietary requirements for vitamin D in older adults are based on limited evidence. Objective: The objective was to establish the dietary intake of vitamin D required to maintain serum 25-hydroxyvitamin D [25(OH)D] concentrations above various cutoffs between 25 and 80 nmol/L during wintertime, which accounted for the effect of summer sunshine exposure and diet. Design: A randomized, placebo-controlled, double-blind, 22-wk intervention was conducted in men and women aged >= 64 y (n = 225) at supplemental levels of 0, 5, 10, and 15 mu g vitamin D3/d from October 2007 to March 2008. Results: Clear dose-related increments (P 0.0001) in serum 25(OH)D were observed with increasing supplemental vitamin D-3 intakes. The slope of the relation between total vitamin D intake and serum 25(OH)D was 1.97 nmol . L-1 . mu g intake(-1). The vitamin D intake that maintained serum 25(OH)D concentrations >25 nmol/L in 97.5% of the sample was 8.6 mu g/d. Intakes were 7.9 and 11.4 mu g/d in those who reported a minimum of 15 min daily summer sunshine exposure or less, respectively. The intakes required to maintain serum 25(OH)D concentrations of >37.5, >50, and >80 nmol/L in 97.5% of the sample were 17.2, 24.7, and 38.7 mu g/d, respectively. Conclusion: To ensure that the vitamin D requirement is met by the vast majority (>97.5%) of adults aged >= 64 y during winter, between 7.9 and 42.8 mu g vitamin D/d is required, depending on summer sun exposure and the threshold of adequacy of 25(OH)D. This trial was registered at http://www.controlled-trials.com/ISRCTN20236112 as ISRCTN registration no. ISRCTN20236112. Am J Clin Nutr 2009;89:1366-74.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Northern Ireland Centre for Food and Health (NICHE)
ID Code:3554
Deposited By:Dr Julie Wallace
Deposited On:15 Dec 2009 14:51
Last Modified:11 Feb 2013 15:30

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