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SUBSTANCE-P, NEUROKININ-A AND CALCITONIN GENE-RELATED PEPTIDE DURING DEVELOPMENT OF THE RAT GASTROINTESTINAL-TRACT

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Flatt, Peter, Swanstonflatt, SK, Bailey, CJ, McGregor, GP and Conlon, JM (1991) SUBSTANCE-P, NEUROKININ-A AND CALCITONIN GENE-RELATED PEPTIDE DURING DEVELOPMENT OF THE RAT GASTROINTESTINAL-TRACT. REGULATORY PEPTIDES, 33 (3). pp. 313-320. [Journal article]

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Abstract

Substance P, neurokinin A and calcitonin gene-related peptide (CGRP) were determined in the stomach and small intestine of rats during late foetal development and up to 35 days postnatal life. Concentrations of substance P in stomach and intestine increased from 14 gestational days to 3 days postpartum, and declined thereafter. Concentrations of neurokinin A in stomach declined from 14 days gestation over the period 3-35 postnatal days. In the intestine, concentrations of neurokinin A increased steadily from 14 days gestation to 21-35 postnatal days. Concentrations of CGRP in stomach and intestine declined from 14 days gestation to 7 postnatal days. Thereafter, concentrations of CGRP increased in both stomach and intestine. Total contents of each of the three peptides increased progressively with gestational and postnatal age in parallel with increasing stomach and intestinal weights. The results demonstrate different patterns of change in the concentrations of substance P, neurokinin A and CGRP during the dynamic phases of growth and maturation of the gastrointestinal tract in the foetal and postnatal rat.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Diabetes
ID Code:3200
Deposited By:Professor Peter Flatt
Deposited On:08 Jan 2010 11:31
Last Modified:25 Jul 2011 11:06

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