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CYTOCHROME-P450-DEPENDENT MIXED-FUNCTION OXIDASE AND GLUTATHIONE-S-TRANSFERASE ACTIVITIES IN SPONTANEOUS OBESITY-DIABETES

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Barnett, CR, Abbott, RA, Bailey, CJ, Flatt, Peter and Ioannides, C (1992) CYTOCHROME-P450-DEPENDENT MIXED-FUNCTION OXIDASE AND GLUTATHIONE-S-TRANSFERASE ACTIVITIES IN SPONTANEOUS OBESITY-DIABETES. BIOCHEMICAL PHARMACOLOGY, 43 (8). pp. 1868-1871. [Journal article]

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Abstract

The effect of non-insulin-dependent diabetes on the hepatic microsomal cytochrome P450-dependent mixed-function oxidase system and on cytosolic glutathione S-transferase activity was determined using the spontaneously obese-diabetic (ob/ob) mouse model. The activities of the xenobiotic-metabolizing cytochrome P450 proteins were monitored by the use of chemical probes. Non-insulin-dependent diabetes did not influence the hepatic metabolism of substrates associated with the P450 I, IIB. IIE. III and IV families of cytochromes. In contrast, cytosolic glutathione S-transferase activity was markedly reduced and glutathione levels were significantly lowered. These findings raise the possibility that patients suffering from this disease may be more susceptible to chemicals that rely on glutathione conjugation for their deactivation.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Diabetes
ID Code:3190
Deposited By:Professor Peter Flatt
Deposited On:08 Jan 2010 11:59
Last Modified:22 Jul 2011 14:18

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