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SEX-DIFFERENCES IN THE DIABETES-INDUCED MODULATION OF RAT HEPATIC CYTOCHROME-P450 PROTEINS

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Barnett, CR, Rudd, S, Flatt, Peter and Ioannides, C (1993) SEX-DIFFERENCES IN THE DIABETES-INDUCED MODULATION OF RAT HEPATIC CYTOCHROME-P450 PROTEINS. BIOCHEMICAL PHARMACOLOGY, 45 (2). pp. 313-319. [Journal article]

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Abstract

Sex differences in the diabetes-induced changes in hepatic cytochrome P450 proteins were investigated in rats treated with streptozotocin. Changes in specific cytochrome P450 proteins were monitored using diagnostic substrates and immunologically utilizing specific polyclonal antibodies. When expressed in terms of nmoles of total cytochrome P450, ethoxyresorufin O-deethylase activity was increased by treatment with streptozotocin, the extent of induction being the same in the two sexes. In contrast, lauric acid hydroxylase and ethylmorphine N-demethylase activities were induced only in the male rat. Finally, p-nitrophenol hydroxlylase and pentoxyresorufin O-alkylase were enhanced by the same treatment in both sexes, the effect being more pronounced in the male. These findings indicate that sex-specific changes in certain cytochrome P450 proteins exist in response to insulin-dependent diabetes but these cannot, however, be ascribed to sex differences in the severity of diabetes induced by streptozotocin since the degrees of hyperketonaemia and hyperglycaemia were the same in the two sexes. These are likely to reflect sex-specific differences in growth hormone and triglyceride levels in the diabetic animals.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Diabetes
ID Code:3184
Deposited By:Professor Peter Flatt
Deposited On:08 Jan 2010 12:09
Last Modified:22 Jul 2011 14:17

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