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PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Eliasson, L, Renstrom, E, Ammala, C, Berggren, PO, Bertorello, AM, Bokvist, K, Chibalin, A, Deeney, JT, Flatt, Peter, Gabel, J, Gromada, J, Larsson, O, Lindstrom, P, Rhodes, CJ and Rorsman, P (1996) PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells. SCIENCE, 271 (5250). pp. 813-815. [Journal article]

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Abstract

Hypoglycemic sulfonylureas represent a group of clinically useful antidiabetic compounds that stimulate insulin secretion from pancreatic beta cells. The molecular mechanisms involved are not fully understood but are believed to involve inhibition of potassium channels sensitive to adenosine triphosphate (K-ATP channels) in the beta cell membrane, causing membrane depolarization, calcium influx, and activation of the secretory machinery. In addition to these effects, sulfonylureas also promoted exocytosis by direct interaction with the secretory machinery not involving closure of the plasma membrane K-ATP channels. This effect was dependent on protein kinase C (PKC) and was observed at therapeutic concentrations of sulfonylureas, which suggests that it contributes to their hypoglycemic action in diabetics.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Diabetes
ID Code:3165
Deposited By:Professor Peter Flatt
Deposited On:08 Jan 2010 13:17
Last Modified:11 Jun 2010 13:20

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