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Amino acid oxidation in BRIN-BD11 islet cells

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Rasschaert, J, Flatt, Peter, McClenaghan, Neville and Malaisse, WJ (1996) Amino acid oxidation in BRIN-BD11 islet cells. MEDICAL SCIENCE RESEARCH, 24 (10). pp. 691-692. [Journal article]

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Abstract

The oxidation of D-[U-C-14[glucose, L-[1-C-14]leucine, L-[U-C-14]leucine, L-[U-C-14]glutamine and L[U-C-14]arginine by BRIN-BD11 cells, which represent a novel insulin-secreting cell line obtained by electrofusion of tumoural and normal islet cells, was compared to the oxidation of the same nutrients in the parent tumoural RINm5F cells. The oxidation of D-[U-C-14]glucose, L[U-C-14]glutamine and L-[U-C-14]arginine by BRIN-BD11 cells was equal to or higher than that found in RINm5F cells, whilst the opposite situation prevailed in the case of C-14-labelled L-leucine. These findings suggest a more efficient contribution of the Krebs cycle to overall ATP generation in the hybrid cells than in the parent tumoural cells.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Diabetes
ID Code:3149
Deposited By:Professor Peter Flatt
Deposited On:08 Jan 2010 13:37
Last Modified:15 Jun 2011 11:10

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