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Long-term beneficial effects of vanadate, tungstate, and molybdate on insulin secretion and function of cultured beta cells

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Liu, HK, Green, BD, McClenaghan, Neville, McCluskey, Janie and Flatt, Peter (2004) Long-term beneficial effects of vanadate, tungstate, and molybdate on insulin secretion and function of cultured beta cells. PANCREAS, 28 (4). pp. 364-368. [Journal article]

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Abstract

The ultratrace elements vanadate, tungstate, and molybdate exhibit significant antihyperglycemic effects in both type 1 and 2 diabetic animals, but possible effects on the function of pancreatic beta cells are understudied. In the present study, clonal BRIN BD11 cells were cultured for 3 days with each ultratrace element to establish doses lacking detrimental effects on viable beta cell mass. Vanadate treatment ( 4 mumol/L) had no effect on cellular insulin content but improved glucose-induced insulin secretory responsiveness. However, insulin secretion mediated by PKA and PKC activation was desensitized in vanadate-treated cells. Culture with tungstate ( 300 mumol/L) and molybdate ( 1 mmol/L) increased cellular insulin content and enhanced basal insulin release and the responsiveness to glucose and a wide range of other secretagogues. These observations suggest significant effects of ultratrace elements on pancreatic beta cells that may contribute to their antihyperglycemic action.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Diabetes
ID Code:3014
Deposited By:Professor Peter Flatt
Deposited On:14 Jan 2010 15:41
Last Modified:15 Jun 2011 11:10

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