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Meal-dependent regulation of circulating glycated insulin in type 2 diabetic subjects

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

McKillop, Aine, Lindsay, JR, Au, S, Mahood, KI, O'Harte, Finbarr, Flatt, Peter and Bell, PM (2006) Meal-dependent regulation of circulating glycated insulin in type 2 diabetic subjects. HORMONE AND METABOLIC RESEARCH, 38 (2). pp. 94-97. [Journal article]

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DOI: 10.1055/s-2006-925125

Abstract

There is mounting evidence that elevated circulating concentrations of glycated insulin play a role in insulin resistance in type 2 diabetes. This study evaluated the secretion of glycated insulin in response to enteral stimulation in type 2 diabetic subjects. Following a mixed meal (450 kcal; 44% carbohydrate; 40% fat; 16% protein), glycated insulin rose 10-fold to peak (60 min) at 104.5 +/- 25.0 pmol/l (p < 0.001), representing 22% total circulating insulin. The response paralleled early rises in insulin and C-peptide, which peaked at 90 min and were more protracted. Maximum glucose concentrations were observed at 50 min. These data indicate that type 2 diabetic subjects exhibit a rapid meal-induced release of glycated insulin from readily releasable pancreatic beta-cell stores, which might contribute to impaired glucose homeostasis following enteral nutrition.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute > Diabetes
ID Code:2984
Deposited By:Professor Peter Flatt
Deposited On:18 Dec 2009 09:48
Last Modified:28 Feb 2011 11:07

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