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Abdel-Wahab, Yasser, Marenah, Lamin, Flatt, Peter and Conlon, J. Michael (2007) Insulin releasing properties of the temporin family of antimicrobial peptides. PROTEIN AND PEPTIDE LETTERS, 14 (7). pp. 702-707. [Journal article]
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Abstract
Temporin-1Vb, -1Oe, -1DRb, and -1TGb (10(-8) - 10(-6)M) produced significant (p<0.05) and concentration-dependent stimulatory effects on insulin secretion from clonal rat BRIN-BD11 cells without increased release of lactate dehydrogenase. Temporin-1Va and temporin-1Vc (10(-8) - 10(-6)M) also stimulated insulin-release but were cytotoxic at 10(-6)M. Temporin-1DRa was without effect. The temporins at 10(-7) M had no effect on intracellular calcium concentrations suggesting that they stimulate insulin release via a K-ATP channel-independent pathway.
| Item Type: | Journal article |
|---|---|
| Faculties and Schools: | Faculty of Life and Health Sciences Faculty of Life and Health Sciences > School of Biomedical Sciences |
| Research Institutes and Groups: | Biomedical Sciences Research Institute Biomedical Sciences Research Institute > Diabetes |
| ID Code: | 2919 |
| Deposited By: | Professor Peter Flatt |
| Deposited On: | 17 Dec 2009 15:02 |
| Last Modified: | 09 Jun 2010 11:18 |
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