Ulster University Logo

Ulster Institutional Repository

Insulin releasing properties of the temporin family of antimicrobial peptides

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Abdel-Wahab, Yasser, Marenah, Lamin, Flatt, Peter and Conlon, J. Michael (2007) Insulin releasing properties of the temporin family of antimicrobial peptides. PROTEIN AND PEPTIDE LETTERS, 14 (7). pp. 702-707. [Journal article]

Full text not available from this repository.

Abstract

Temporin-1Vb, -1Oe, -1DRb, and -1TGb (10(-8) - 10(-6)M) produced significant (p<0.05) and concentration-dependent stimulatory effects on insulin secretion from clonal rat BRIN-BD11 cells without increased release of lactate dehydrogenase. Temporin-1Va and temporin-1Vc (10(-8) - 10(-6)M) also stimulated insulin-release but were cytotoxic at 10(-6)M. Temporin-1DRa was without effect. The temporins at 10(-7) M had no effect on intracellular calcium concentrations suggesting that they stimulate insulin release via a K-ATP channel-independent pathway.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Diabetes
ID Code:2919
Deposited By:Professor Peter Flatt
Deposited On:17 Dec 2009 15:02
Last Modified:09 Jun 2010 11:18

Repository Staff Only: item control page