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Captopril and its synthesis from chiral intermediates

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Chirumamilla, RR, Marchant, R and Singh - Nee Nigam, Poonam (2001) Captopril and its synthesis from chiral intermediates. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 76 (2). pp. 123-127. [Journal article]

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Abstract

Captopril is an antihypertensive agent that inhibits the angiotensin-converting enzyme of the renin-angiotensin system. Chiral intermediates are used in the synthesis of the drug. These intermediates are obtained by resolution of racemic compounds or by chemical, biocatalytic methods and or by asymmetric synthesis by biocatalytic process. This article reviews the various chemical and biochemical processes involved in the synthesis of the chiral drug, including the pharmacological action of captopril. (C) 2001 Society of Chemical Industry.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Infection and Immunity/Microbiology
ID Code:2740
Deposited By:Professor Roger Marchant
Deposited On:15 Dec 2009 16:29
Last Modified:04 Aug 2011 09:47

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