Brugnara, Laura, Vinaixa, Maria, Murillo, Serafin, Samino, Sara, Rodriguez, Miguel Angel, Beltran , Antoni, Lerin, Carles, Davison, Gareth, Correig, Xavier and Novials, Anna (2012) Metabolomics Approach for Analyzing the Effects of Exercise in Subjects with Type 1 Diabetes Mellitus. Plos ONE8 pp, DOI: 10.1371/journal.pone.0040600 [Internet publication]
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The beneficial effects of exercise in patients with type 1 diabetes (T1D) are not fully proven, given that it may occasionally induce acute metabolic disturbances. Indeed, the metabolic disturbances associated with sustained exercise may lead to worsening control unless great care is taken to adjust carbohydrate intake and insulin dosage. In this work, pre- and postexercise metabolites were analyzed using a 1H-NMR and GC-MS untargeted metabolomics approach assayed in serum. We studied ten men with T1D and eleven controls matched for age, body mass index, body fat composition, and cardiorespiratory capacity, participated in the study. The participants performed 30 minutes of exercise on a cycleergometer at 80% VO2max. In response to exercise, both groups had increased concentrations of gluconeogenic precursors (alanine and lactate) and tricarboxylic acid cycle intermediates (citrate, malate, fumarate and succinate). The T1D group, however, showed attenuation in the response of these metabolites to exercise. Conversely to T1D, the control group also presented increases in a-ketoglutarate, alpha-ketoisocaproic acid, and lipolysis products (glycerol and oleic and linoleic acids), as well as a reduction in branched chain amino acids (valine and leucine) determinations. The T1D patients presented a blunted metabolic response to acute exercise as compared to controls. This attenuated response may interfere in the healthy performance or fitness of T1D patients, something that further studies should elucidate.
|Item Type:||Internet publication|
|Faculties and Schools:||Faculty of Life and Health Sciences|
Faculty of Life and Health Sciences > Ulster Sports Academy
|Research Institutes and Groups:||Sport and Exercise Sciences Research Institute|
Sport and Exercise Sciences Research Institute > Centre for Physical Activity and Health
|Deposited By:||Miss Fiona McAuley|
|Deposited On:||20 Nov 2012 09:57|
|Last Modified:||20 Nov 2012 09:57|
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