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Structural Probes in Quadruplex Nucleic Acid StructureDetermination by NMR

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Karsisiotis, Ioannis and Webba da Silva, Mateus (2012) Structural Probes in Quadruplex Nucleic Acid StructureDetermination by NMR. Molecules, 17 . pp. 13073-13086. [Journal article]


DOI: 10.3390/molecules171113073


Traditionally, isotope-labelled DNA and RNA have been fundamental to nucleicacid structural studies by NMR. Four-stranded nucleic acid architectures studiesincreasingly benefit from a plethora of nucleotide conjugates for resonance assignments,the identification of hydrogen bond alignments, and improving the population of preferredspecies within equilibria. In this paper, we review their use for these purposes. Mostimportantly we identify reasons for the failure of some modifications to result inquadruplex formation.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Molecular Medicine
ID Code:23943
Deposited By:Dr Mateus Webba da Silva
Deposited On:12 Nov 2012 11:55
Last Modified:22 Nov 2012 11:52

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