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Diagnostic and prognostic biomarker discovery strategies for autoimmune disorders

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Gibson, David, Banha, Joao, Penque, Deborah, Costa, Luciana, Conrads, Thomas, Cahill, Delores, O'Brien, John and Rooney, Madeleine (2010) Diagnostic and prognostic biomarker discovery strategies for autoimmune disorders. Journal of Proteomics, 73 . pp. 1045-1060. [Journal article]

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DOI: 10.1016/j.jprot.2009.11.013

Abstract

Current clinical, laboratory or radiological parameters cannot accurately diagnose or predictdisease outcomes in a range of autoimmune disorders. Biomarkers which can diagnose atan earlier time point, predict outcome or help guide therapeutic strategies in autoimmunediseases could improve clinical management of this broad group of debilitating disorders.Additionally, there is a growing need for a deeper understanding of multi-factorialautoimmune disorders.Proteomic platforms offering a multiplex approach are more likely to reflect the complexityof autoimmune disease processes. Findings from proteomic based studies of three distinctautoimmune diseases are presented and strategies compared. It is the authors' view thatsuch approaches are likely to be fruitful in the movement of autoimmune disease treatmentaway from reactive decisions and towards a preventative stand point.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Stratified Medicine
ID Code:23528
Deposited By:Dr David Gibson
Deposited On:08 Oct 2012 09:31
Last Modified:15 Oct 2013 15:59

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