Ulster University Logo

Ulster Institutional Repository

Sustained release of proteins from a modified vaginal ring device

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Morrow, Ryan J, Woolfson, A David, Donnelly, Louise, Curran, Rhonda M, Andrews, Gavin P, Katinger, Dietmar and Malcolm, R Karl (2011) Sustained release of proteins from a modified vaginal ring device. European Journal of Pharmaceutics and Biopharmaceutics, 77 . pp. 3-10. [Journal article]

[img]PDF - Accepted Version
Indefinitely restricted to Repository staff only.

792Kb

URL: http://ac.els-cdn.com/S0939641110002845/1-s2.0-S0939641110002845-main.pdf?_tid=b8c25cc7e757d6a24bddc7311a768580&acdnat=1345815829_c66454a137c6f27a3792019ac6fce3aa

DOI: 10.1016/j.ejpb.2010.10.010

Abstract

A new vaginal ring technology, the insert vaginal ring (InVR), is presented. The InVR overcomes the current shortfall of conventional vaginal rings (VRs) that are generally ineffectual for the delivery of hydrophilic and/or macromolecular actives, including peptides, proteins and antibodies, due to their poor permeation characteristics in the hydrophobic polymeric elastomers from which VRs are usually fabricated. Release of the model protein BSA from a variety of insert matrices for the InVR is demonstrated, including modified silicone rods, directly compressed tablets and lyophilised gels, which collectively provided controlled release profiles from several hours to beyond 4 weeks. Furthermore, the InVR was shown to deliver over 1 mg of the monoclonal antibody 2F5 from a single device, offering a potential means of protecting women against the transmission of HIV.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Nursing
Research Institutes and Groups:Institute of Nursing and Health Research
Institute of Nursing and Health Research > Maternal, Fetal and Infant Research
ID Code:23183
Deposited By:Dr Rhonda Curran
Deposited On:28 Aug 2012 14:56
Last Modified:28 Aug 2012 14:56

Repository Staff Only: item control page