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EFFECT OF CYCLOSPORINE ON IMMUNE-COMPLEX DEPOSITION IN MURINE GLOMERULONEPHRITIS

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Quinn, Daniel, FENNELL, JS, SHEILS, O, GAFFNEY, EF and FEIGHERY, CF (1991) EFFECT OF CYCLOSPORINE ON IMMUNE-COMPLEX DEPOSITION IN MURINE GLOMERULONEPHRITIS. IMMUNOLOGY, 72 (4). pp. 550-554. [Journal article]

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Abstract

Chronic glomerulonephritis (GN) was induced in N/M mice by daily injections of human serum albumin (HSA). The glomerular lesion was similar to that observed in human membranous GN and was characterized by intense mesangial and capillary loop immunofluorescent staining for HSA, IgG and C3. Electron microscopic examination revealed numerous electron-dense deposits in the mesangium and along the subepithelial side of the glomerular basement membrane, the latter deposits being associated with membranous spikes. Chronically injected mice that had been treated with cyclosporin (CsA) from Day 1 had different patterns of immune complex deposition. Mesangial deposition was apparently unaltered but no subepithelial deposits or spikes were evident. In addition, only two out of 21 HSA-injected mice which began CsA treatment on Day 21 had subepithelial deposits. There was no significant difference in serum levels of HSA-specific IgG between the three groups of mice. CsA treatment would therefore appear to ameliorate the immunopathology of antigen-induced glomerulonephritis in this model without affecting serum antibody levels, and may be of therapeutic value in the treatment of human membranous GN.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
ID Code:22911
Deposited By:Dr Daniel Quinn
Deposited On:31 Jul 2012 12:20
Last Modified:31 Jul 2012 12:20

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